p-dodecylphenylsulphonylhydrazide | 76923-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-dodecylphenylsulphonylhydrazide
• 英文别名: 4-Dodecylbenzenesulfonohydrazide
• CAS: 76923-97-2
• 化学式: C₁₈H₃₂N₂O₂S
• 分子量: 340.53
• InChiKey: ROSYLLGHEFMEKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  p-dodecylphenylsulphonylhydrazide 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 proline p-dodecylphenylsulphonylhydrazide
  参考文献：
  名称：

  Synthesis of functionalized chromones via organocatalysis

  摘要：

  A facile and versatile organocatalytic approach to access 2-substituted and 2,3-disubstituted chromone derivatives under mild conditions was developed, which was effectively catalyzed by novel proline phenylsulphonylhydrazide or pyrrolidine. As a result, diversely functionalized chromones were obtained in up to 99% yield. In addition, further modification of the corresponding chromones afforded novel polycyclic chromones. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.10.045
• 作为产物：
  描述：

  对十二烷基苯磺酰氯 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 p-dodecylphenylsulphonylhydrazide
  参考文献：
  名称：

  Synthesis of functionalized chromones via organocatalysis

  摘要：

  A facile and versatile organocatalytic approach to access 2-substituted and 2,3-disubstituted chromone derivatives under mild conditions was developed, which was effectively catalyzed by novel proline phenylsulphonylhydrazide or pyrrolidine. As a result, diversely functionalized chromones were obtained in up to 99% yield. In addition, further modification of the corresponding chromones afforded novel polycyclic chromones. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.10.045

文献信息

• Stereoselective Synthesis of α-Alkyl-β-keto Imides via Asymmetric Redox C−C Bond Formation between α-Alkyl-α-diazocarbonyl Compounds and Aldehydes
  作者：Takuya Hashimoto、Hisashi Miyamoto、Yuki Naganawa、Keiji Maruoka

  DOI：10.1021/ja903500w

  日期：2009.8.19

  Asymmetric redox C-C bond formation between alpha-alkyl-alpha-diazocarbonyl compounds and aldehydes was developed as a practical and general method for the construction of alpha-alkyl-beta-keto imides having a chiral nonracemic tertiary stereogenic center.