(3aR,5R,6aS)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-dihydro-furo[2,3-d][1,3]dioxol-6-one | 258264-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (3aR,5R,6aS)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-dihydro-furo[2,3-d][1,3]dioxol-6-one
• 英文别名: (3aR,5R,6aS)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(trichloromethyl)-3a,6a-dihydrofuro[2,3-d][1,3]dioxol-6-one
• CAS: 258264-29-8
• 化学式: C₁₁H₁₃Cl₃O₆
• 分子量: 347.58
• InChiKey: XRQKCCGWCYCWSG-JOHDSVJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3aR,5R,6aS)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-dihydro-furo[2,3-d][1,3]dioxol-6-one 在 盐酸 、 盐酸羟胺 、 sodium cyanoborohydride 作用下， 以 吡啶 为溶剂， 生成 N-[(3aR,5S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-hydroxylamine
  参考文献：
  名称：

  New α-chloralose derivatives

  摘要：

  Chloralose is an easily available carbohydrate derivative bearing biological properties. It constitutes a convenient starting material for various synthetic developments. Herein we describe the preparation of hydroxylamino derivatives of alpha-chloralose using well-established synthetic procedures. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00098-1
• 作为产物：
  描述：

  (3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 生成 (3aR,5R,6aS)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-trichloromethyl-dihydro-furo[2,3-d][1,3]dioxol-6-one
  参考文献：
  名称：

  New α-chloralose derivatives

  摘要：

  Chloralose is an easily available carbohydrate derivative bearing biological properties. It constitutes a convenient starting material for various synthetic developments. Herein we describe the preparation of hydroxylamino derivatives of alpha-chloralose using well-established synthetic procedures. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00098-1