2-Methyl-3-n-propyl-bernsteinsaeureanhydrid | 1195228-31-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Methyl-3-n-propyl-bernsteinsaeureanhydrid
• 英文别名: 2-Methyl-3-propylsuccinic anhydride；3-Methyl-4-propyloxolane-2,5-dione
• CAS: 1195228-31-9
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: TYDHKYYKYIEXLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
  申请人：Cerulean Pharma Inc.

  公开号：US20130196906A1

  公开（公告）日：2013-08-01

  Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of a disease or disorder, e.g., autoimmune disease, inflammatory disease, central nervous system disorder, cardiovascular disease, or metabolic disorder. Also provided are CDP-therapeutic agent conjugates, particles comprising CDP-therapeutic agent conjugates, and compositions comprising CDP-therapeutic agent conjugates.

  提供了关于使用CDP-治疗剂偶联物治疗疾病或紊乱的方法，例如自身免疫疾病、炎症性疾病、中枢神经系统紊乱、心血管疾病或代谢紊乱。还提供了CDP-治疗剂偶联物、包含CDP-治疗剂偶联物的颗粒以及包含CDP-治疗剂偶联物的组合物。
• IMIDE-LINKED MALEIMIDE AND POLYMALEIMIDE COMPOUNDS
  申请人：Mizori Farhad G.

  公开号：US20110130485A1

  公开（公告）日：2011-06-02

  The invention is directed to maleimide thermosets incorporating imide-extended mono-, bis-, or polymaleimide compounds. These imide-extended maleimide compounds are prepared by the condensation of appropriate anhydrides with appropriate diamines to give amine terminated compounds. These compounds are then condensed with excess maleic anhydride to yield imide-extended maleimide compounds.

  这项发明涉及将咪唑烯烃热固性树脂与亚酰亚胺扩展的单、双或多咪唑烯烃化合物结合。这些亚酰亚胺扩展的咪唑烯烃化合物是通过适当的酐与适当的二胺进行缩合反应制备的，以得到末端带有胺基的化合物。然后，这些化合物与过量的马来酸酐缩合，得到亚酰亚胺扩展的咪唑烯烃化合物。
• Method for Treating Surfaces with Copolymers
  申请人：Bouloussa Othman

  公开号：US20080226585A1

  公开（公告）日：2008-09-18

  The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.

  本发明涉及一种处理含有不稳定氢原子的衬底表面的方法，以赋予其细胞毒性或细胞粘附性能。其特征在于，该方法包括至少一步，其中在液体介质中暴露该衬底或其表面至少一种共聚物，该共聚物包含至少一种A型单体单元，包括至少一种反应位点，能够通过共价键连接到该衬底或该表面，以及至少一种B型单体单元，包括至少一种分子，能够赋予该衬底或该表面抗微生物、抗病毒和/或抗真菌性能或细胞粘附性能，该步骤在有效条件下进行，以促进该共聚物与该衬底或其表面的共价嫁接。
• Cyclodextrin-based polymers for therapeutics delivery
  申请人：Cheng Jianjun

  公开号：US20080058427A1

  公开（公告）日：2008-03-06

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型的治疗环糊精含聚合物组合物，其设计为小分子治疗药物的载体，并且涉及其制药组合物。这些含环糊精聚合物可以提高药物的稳定性和溶解度，并在体内使用时降低小分子治疗药物的毒性。此外，通过从各种连接基团和靶向配体中进行选择，这些聚合物提供了治疗剂的控制释放方法。本发明还涉及使用所述治疗组合物治疗受试者的方法。本发明还涉及制药业务的方法，包括制造、许可或分发包含或与所述聚合物化合物相关的试剂盒。
• Dosage forms for movement disorder treatment
  申请人：Nangia Avinash

  公开号：US20070148238A1

  公开（公告）日：2007-06-28

  The invention relates to the improvement in the treatment of certain neural disorders/diseases, such as Parkinson's disease and other motor disorders. One aspect of the invention relates to drug compositions and dosage forms comprising said drug composition. Another aspect of the invention relates to methods of manufacturing the drug compositions and dosage forms. Another aspect of the invention relates to methods of treatment, comprising administering the drug composition and dosage form to an individual.

  本发明涉及改进某些神经疾病/疾病的治疗，例如帕金森病和其他运动障碍。发明的一个方面涉及包含所述药物组合物的药物组合物和剂型。发明的另一个方面涉及制造药物组合物和剂型的方法。发明的另一个方面涉及治疗方法，包括向个体施用药物组合物和剂型。