calcium;disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: calcium;disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
• 化学式: C10H14CaN2Na2O8+2
• 分子量: 376.28
• InChiKey: SHWNNYZBHZIQQV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -16.62
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  169
• 氢给体数：
  2
• 氢受体数：
  8

ADMET

代谢

乙二胺四乙酸钙二钠不被代谢。

Edetate calcium disodium is not metabolized.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

锌补充剂（同时使用可能会因螯合作用而降低乙二胺四乙酸钙和锌补充剂的疗效；在乙二胺四乙酸钙治疗完成之前，应暂停锌补充剂治疗）

Zinc supplements (concurrent use may decrease the effectiveness of edetate calcium disodium and zinc supplements due to chelation; zinc supplement therapy should be withheld until edetate calcium disodium therapy is completed)

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

依地酸钙钠通过螯合锌，干扰锌胰岛素制剂的作用。

Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

同时使用CaNa2EDTA和二巯丙醇（BAL）可以增加铅从组织储库中的动员速率，并且与单独使用CaNa2EDTA相比，可能减少中枢神经系统毒性的发生率。

Concomitant administration of CaNa2EDTA and dimercaprol (BAL) increases the rate of lead mobilization from tissue depots and probably reduces the incidence of central nervous system toxicity when compared with the single use of CaNa2EDTA.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

类固醇增强了动物中依地酸钙钠的肾毒性。

Steroids enhance the renal toxicity of edetate calcium disodium in animals.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

肾脏毒性（例如，急性肾小管坏死、蛋白尿和血尿）可以通过充分的水化、建立充足的尿流量、避免过量用药以及将连续给药限制在5天或更少的天数来最小化。在严重中毒的治疗期间，以及在其他情况下的第二天和第五天，应每天进行肾功能实验室评估。

Nephrotoxicity (e.g., acute tubular necrosis, proteinuria, and hematuria) may be minimized by adequate hydration, establishment of adequate urine flow, avoidance of excessive doses, and limitation of continuous administration to 5 or fewer days. Laboratory assessment of renal function should be performed daily during treatment for severe intoxication and after the second and fifth days in other cases.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

乙二胺四乙酸钙二钠从胃肠道吸收不良。

Edetate calcium disodium is poorly absorbed from the gastrointestinal tract.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

乙二胺四乙酸钙二钠通过肌肉注射或皮下给药吸收良好。当乙二胺四乙酸钙二钠静脉给药用于治疗铅中毒时，螯合铅的尿液排泄在大约1小时内开始，螯合铅的排泄峰值发生在24-48小时内。由铅中毒引起的绞痛可能在2小时内消失，肌肉无力和震颤在4-5天后消失，治疗后4-9天内通常会使粪卟啉尿和红细胞点状减少。

Edetate calcium disodium is well absorbed following IM or subcutaneous administration. When edetate calcium disodium is administered IV in the treatment of lead poisoning, urinary excretion of chelated lead begins within about 1 hour and peak excretion of chelated lead occurs within 24-48 hours. Colic caused by lead poisoning may disappear within 2 hours, muscular weakness and tremors disappear after 4-5 days, and coproporphyrinuria and stippled erythrocytes usually decrease within 4-9 days after therapy is initiated.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

EDTA 钙钠是一种主要用于进入细胞外液的药物。该药物不渗透红细胞...

Edetate calcium disodium is distributed mainly into extracellular fluid. The drug does not penetrate erythrocytes...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

静脉给药后，50%的剂量在1小时内出现在尿液中，95%在24小时内出现。尿液流量和/或pH的变化不会影响依地酸钙钠的排泄率，但肾功能受损，肾小球滤过率降低会延迟药物的排泄，从而可能增加其肾毒性。

Following parenteral administration, it is rapidly excreted by glomerular filtration in urine, either unchanged or as metal chelates. Following IV administration, 50% of a dose appears in urine within 1 hour and 95% within 24 hours. ... Changes in urine flow and/or pH do not affect the excretion rate of edetate calcium disodium, but impaired renal function with reduced glomerular filtration delays excretion of the drug and thus may increase its nephrotoxicity.

来源:Hazardous Substances Data Bank (HSDB)