| 157800-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 157800-33-4
• 化学式: C₄₈H₇₁N₃O₁₂
• 分子量: 882.105
• InChiKey: YVIQUSGOJNURGO-MWAOVGOISA-N

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 盐酸 、 氢气 、 4-吡咯烷基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 30.0h， 生成 cyclo[N(Me)Leu-D-OAla-N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe]
  参考文献：
  名称：

  Synthesis and anthelmintic activity of cyclohexadepsipeptides with cyclohexylmethyl side chains

  摘要：

  Cyclohexadepsipeptides (CHDPs) with cyclohexylmethyl side chains represent novel enniatins with in vivo activity against the parasitic nematode Haemonchus contortus Rudolphi in sheep. It was found that the replacement of benzylic by cyclohexylmethyl side chains on the enniatin skeleton can increase anthelmintic efficacy. Here we report on a simple total synthesis of the precursors for this type of CHDPs and an efficient chemical transformation of the benzylic into the corresponding cyclohexylmethyl side chains. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.037
• 作为产物：
  描述：

  、 在 双(2-氧代-3-恶唑烷基)次磷酰氯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Synthesis and anthelmintic activity of cyclohexadepsipeptides with cyclohexylmethyl side chains

  摘要：

  Cyclohexadepsipeptides (CHDPs) with cyclohexylmethyl side chains represent novel enniatins with in vivo activity against the parasitic nematode Haemonchus contortus Rudolphi in sheep. It was found that the replacement of benzylic by cyclohexylmethyl side chains on the enniatin skeleton can increase anthelmintic efficacy. Here we report on a simple total synthesis of the precursors for this type of CHDPs and an efficient chemical transformation of the benzylic into the corresponding cyclohexylmethyl side chains. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.037