benzyl (2S)-2-[[[(2R,3R,5R)-5-(5-chloro-2,4-dioxo-pyrimidin-1-yl)-4,4-difluoro-3-hydroxy-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate | 1321581-04-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: benzyl (2S)-2-[[[(2R,3R,5R)-5-(5-chloro-2,4-dioxo-pyrimidin-1-yl)-4,4-difluoro-3-hydroxy-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate
• 英文别名: benzyl (2S)-2-[[[(2R,3R,5R)-5-(5-chloro-2,4-dioxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• CAS: 1321581-04-7
• 化学式: C₂₅H₂₅ClF₂N₃O₉P
• 分子量: 615.912
• InChiKey: OATZJDFAZLVRED-ZMZPBXSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2-脱氧-2,2-二氟戊呋喃糖-1-酮 3,5-二安息香酸盐 在 N-甲基咪唑 、 三氟甲磺酸三甲基硅酯 、 sodium methylate 、 lithium tri-t-butoxyaluminum hydride 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 1,1-二氯乙烷 、 二氯甲烷 为溶剂， 反应 53.0h， 生成 benzyl (2S)-2-[[[(2R,3R,5R)-5-(5-chloro-2,4-dioxo-pyrimidin-1-yl)-4,4-difluoro-3-hydroxy-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate
  参考文献：
  名称：

  Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

  摘要：

  We report the synthesis of a series of novel 2'-deoxy-2',2'-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2'-deoxy-2',2'-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.05.037

文献信息

• Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides
  作者：Maurizio Quintiliani、Leentje Persoons、Nicola Solaroli、Anna Karlsson、Graciela Andrei、Robert Snoeck、Jan Balzarini、Christopher McGuigan

  DOI：10.1016/j.bmc.2011.05.037

  日期：2011.7

  We report the synthesis of a series of novel 2'-deoxy-2',2'-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2'-deoxy-2',2'-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.