6-methyl-2-(1-methylbutyl)pyridine | 143814-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-methyl-2-(1-methylbutyl)pyridine
• 英文别名: 2-Methyl-6-pentan-2-ylpyridine
• CAS: 143814-39-5
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: OUPKXRRTUVFKBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5,7-Dimethyl-7-propyl-6,8-dioxa-bicyclo[3.2.1]octane 在 三氯化铝 、 盐酸羟胺 作用下， 以 溶剂黄146 为溶剂， 反应 20.0h， 以84%的产率得到6-methyl-2-(1-methylbutyl)pyridine
  参考文献：
  名称：

  从双环缩酮中一步一步制备2,6-二取代吡啶的新方法

  摘要：

  通过用AlCl 3，-NH 2 OH·HCl / AcOH处理，一步就很容易将6,8-二氧杂双环[3.2.1loctanes（1）转化为2,6-二取代的吡啶衍生物（2）。

  DOI：

  10.1016/s0040-4039(00)61321-7

文献信息

• Benzodiazepine derivatives as RSV inhibitors
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10865215B2

  公开（公告）日：2020-12-15

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了抑制呼吸道合胞病毒（RSV）的式（I）化合物或其药学上可接受的盐、酯或原药。 本发明进一步涉及包含上述化合物的药物组合物，用于给受 RSV 感染的患者用药。 本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者 RSV 感染的方法。
• USP30 inhibitors
  申请人：Mitobridge, Inc.

  公开号：US10968172B2

  公开（公告）日：2021-04-06

  The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.

  该申请涉及结构式 (I) 的苯基或萘基磺酰胺衍生物。这些化合物被描述为 USP30（泛素特异性肽酶 30）的抑制剂，可用于治疗涉及线粒体缺陷的疾病，包括神经退行性疾病（如阿尔茨海默氏症和帕金森氏症）或肿瘤性疾病（如白血病）。
• Jun, Jong-Gab; Shin, Hyun Shun; Kim, Sung Hoon, Journal of the Chemical Society. Perkin transactions I, 1993, # 15, p. 1815 - 1818
  作者：Jun, Jong-Gab、Shin, Hyun Shun、Kim, Sung Hoon

  DOI：——

  日期：——
• APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS
  申请人：PHARMAKEA, INC.

  公开号：US20200048218A1

  公开（公告）日：2020-02-13

  Described herein are ASK1 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with ASK1 activity.
• USP30 INHIBITORS
  申请人：Mitobridge, Inc.

  公开号：US20200131121A1

  公开（公告）日：2020-04-30

  The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.