4,5-dihydro-α-(2-methylpropyl)-5-oxo-(S)-1,2-benzothiazepine-2(3H)-acetic acid methyl ester 1,1-dioxide | 1153686-98-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,5-dihydro-α-(2-methylpropyl)-5-oxo-(S)-1,2-benzothiazepine-2(3H)-acetic acid methyl ester 1,1-dioxide
• CAS: 1153686-98-6
• 化学式: C₁₆H₂₁NO₅S
• 分子量: 339.412
• InChiKey: HFCRFKPOJQKBPN-ZDUSSCGKSA-N

物化性质

• 沸点：
  486.4±55.0 °C(predicted)
• 密度：
  1.256±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  4,5-dihydro-5-methylene-α-(2-methylpropyl)-(S)-1,2-benzothiazepine-2(3H)-acetic acid methyl ester 1,1-dioxide 在 臭氧 、 苏丹红 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以82%的产率得到4,5-dihydro-α-(2-methylpropyl)-5-oxo-(S)-1,2-benzothiazepine-2(3H)-acetic acid methyl ester 1,1-dioxide
  参考文献：
  名称：

  α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams

  摘要：

  The development of new methods to skeletally diverse sultams based oil a central alpha-halo benzene sulfonamide building block is reported. Several salient features of this building block are Utilized ill multiple reaction pathways, including the Fleck reaction, C- and O-arylation, Sonogashira-Pauson-Khand, Sonogashira-intramolecular hydroamination, and domino aza-Michael-Heck for the generation of five-, six-, and seven-membered benzofused bicyclic and tricyclic sultams. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.053