(+/-)-2-Amino-4-pentylmercapto-buttersaeure | 23513-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-2-Amino-4-pentylmercapto-buttersaeure
• 英文别名: S-pentyl-homocysteine；S-Pentyl-homocystein；DL-2-Amino-4-pentylmercapto-buttersaeure；2-Amino-4-pentylsulfanylbutanoic acid
• CAS: 23513-68-0
• 化学式: C₉H₁₉NO₂S
• 分子量: 205.321
• InChiKey: CTFZVTAVEJZRSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• OXIDASE, POLYNUCLEOTIDE THAT CODES FOR SAME, AND USES FOR BOTH
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3168302A1

  公开（公告）日：2017-05-17

  A polynucleotide encoding an amino acid sequence represented by SEQ ID NO: 1 or 3; a protein having an amino acid sequence represented by SEQ ID NO: 1 or 3; and; a method for producing an L-α-amino acid compound, which comprises the step (1) for reacting the present invented protein with an α-hydroxycarboxylic acid compound to obtain a corresponding α-oxocarboxylic acid compound, and the step of reacting a protein having the ability to aminate an α-oxocarboxylic acid compound and convert the same into a corresponding L-α-amino acid compound with the α-oxocarboxylic acid compound obtained in the step (1) to obtain a corresponding L-α-amino acid compound; and the like.

  编码由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的多核苷酸；具有由 SEQ ID NO：1或3所代表的氨基酸序列的蛋白质；以及一种生产 L-α-氨基酸化合物的方法，该方法包括步骤(1)，将本发明的蛋白质与 α-羟基羧酸化合物反应，得到相应的 α-氧代羧酸化合物、以及将具有氨化α-氧羧酸化合物并将其转化为相应的 L-α-氨基酸化合物的能力的蛋白质与步骤（1）中获得的α-氧羧酸化合物反应，以获得相应的 L-α-氨基酸化合物的步骤；等。
• BORON-CONTAINING COMPOUND
  申请人：Stella Pharma Corporation

  公开号：EP3492477A1

  公开（公告）日：2019-06-05

  To provide a novel boron-containing compound. A compound represented by the following formula: wherein black circle represents B, white circles represent B-H; -R1 represents -(CH2)n-X1-R3 (n represents an integer of 0 to 6; X1 represents O, S, NH, S-S, O-CO, NHCO or SCO, or does not exist; R3 represents C6-C20 alkyl, hydroxy C6-C20 alkyl, amino C6-C20 alkyl, azido C6-C20 alkyl, hydroxycarbonyl C6-C20 alkyl, or the like), or a group having a repeating sequence of -(CH2)2-O- 3 times or more and 10 times or less and having a methyl group or an ethyl group at the end on the oxygen atom side; and -R2 is - (CH2)m-X2-R4 (m represents an integer from 0 to 8; X2 represents O, S, NH, S-S, O-CO, NHCO or SCO, or does not exist; and R4 represents a tumor recognition moiety), or does not exist are prepared and used.

  提供一种新型含硼化合物。一种由下式代表的化合物：其中黑圈代表B，白圈代表B-H；-R1代表-(CH2)n-X1-R3（n代表0至6的整数；X1代表O、S、NH、S-S、O-CO、NHCO或SCO，或不存在；R3代表C6-C20烷基、羟基 C6-C20烷基、氨基 C6-C20烷基、叠氮 C6-C20烷基、羟基羰基 C6-C20烷基或类似物），或重复序列为-( )2-O- 3 次或以上、10 次或以下且末端在氧原子一侧具有甲基或乙基的基团；和-R2 是-( )m-X2-R4（m 代表 0 至 8 的整数；X2 代表 O、S、NH、S-S、O-CO、NHCO 或 SCO，或不存在；R4 代表肿瘤识别基团），或不存在的基团制备和使用。
• Oxidase, polynucleotide that codes for same, and use thereof
  申请人：Sumitomo Chemical Company

  公开号：US10351829B2

  公开（公告）日：2019-07-16

  A polynucleotide encoding an amino acid sequence represented by SEQ ID NO: 1 or 3; a protein having an amino acid sequence represented by SEQ ID NO: 1 or 3; and a method for producing an L-α-amino acid compound are provided. The method includes a step (1) of reacting the protein described herein with an α-hydroxycarboxylic acid compound to obtain a corresponding α-oxocarboxylic acid compound; and a step of reacting a protein having the ability to aminate an α-oxocarboxylic acid compound and convert the same into a corresponding L-α-amino acid compound with the α-oxocarboxylic acid compound obtained in step (1) to obtain a corresponding L-α-amino acid compound.

  本发明提供了一种编码由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的多核苷酸；一种具有由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的蛋白质；以及一种生产 L-α-氨基酸化合物的方法。该方法包括步骤(1)，将本文所述的蛋白质与α-羟基羧酸化合物反应，得到相应的α-氧代羧酸化合物；以及步骤(2)，将具有氨化α-氧代羧酸化合物并将其转化为相应的L-α-氨基酸化合物的能力的蛋白质与步骤(1)中得到的α-氧代羧酸化合物反应，得到相应的L-α-氨基酸化合物。
• Method for producing L-α-amino acid compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：US10364448B2

  公开（公告）日：2019-07-30

  Isolated oxidases, isolated polynucleotides encoding the oxidases, and methods of using the oxidases to produce α-oxocarboxylic acid compounds or L-α-amino acid compounds are described.

  本文描述了分离的氧化酶、编码氧化酶的分离多核苷酸以及使用氧化酶生产α-氧代羧酸化合物或L-α-氨基酸化合物的方法。
• OXIDASE, POLYNUCLEOTIDE ENCODING SAME, AND USE OF THESE
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3168301B1

  公开（公告）日：2019-11-20