(9H-Fluoren-9-ylmethoxycarbonylamino)-acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester | 239449-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (9H-Fluoren-9-ylmethoxycarbonylamino)-acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester
• CAS: 239449-16-2
• 化学式: C₃₃H₃₉NO₇
• 分子量: 561.675
• InChiKey: STNKIUXKCLMGKU-PTXPMSOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.14
• 重原子数：
  41.0
• 可旋转键数：
  9.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  98.92
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (9H-Fluoren-9-ylmethoxycarbonylamino)-acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester 在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2,5-dioxopyrrolidin-1-yl) 8-[[2-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-2-oxoethyl]amino]-8-oxooctanoate
  参考文献：
  名称：

  Degradation of target protein in living cells by small-molecule proteolysis inducer

  摘要：

  Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function post-translationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI). (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.042
• 作为产物：
  描述：

  Fmoc-甘氨酸 、 5-甲氧基-4-[2-甲基-3-(3-甲基丁-2-烯基)环氧乙烷-2-基]-1-氧杂螺[2.5]辛烷-6-醇 在 草酰氯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (9H-Fluoren-9-ylmethoxycarbonylamino)-acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester
  参考文献：
  名称：

  Degradation of target protein in living cells by small-molecule proteolysis inducer

  摘要：

  Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function post-translationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI). (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.042