1-(cyclopropylmethyl)-N-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | 1296200-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(cyclopropylmethyl)-N-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide
• 英文别名: 1-(cyclopropylmethyl)-N-[2-(dimethylamino)ethyl]-N-[(3-methoxyphenyl)methyl]-6-(1H-pyrazol-4-yl)indazole-3-carboxamide
• CAS: 1296200-59-3
• 化学式: C₂₇H₃₂N₆O₂
• 分子量: 472.59
• InChiKey: BVIJWMNFFLDOKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  79.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC HETEROARYLS AS KINASE INHIBITORS<br/>[FR] HÉTÉROARYLES BICYCLIQUES FORMANT INHIBITEURS DE LA KINASE
  申请人：FENG YANGBO

  公开号：WO2011050245A1

  公开（公告）日：2011-04-28

  The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

  该发明涉及对各种激酶酶的抑制剂作为杂环芳基化合物的用途。在各种实施形式中，该发明提供了一种具有抑制生物活性的杂环芳基化合物，该生物活性与Rho激酶、AKT激酶、p70S6K激酶、LIM激酶、IKK激酶、Flt激酶、Aurora激酶或Src激酶或其任意组合相关。该发明的化合物包括具有式(I)的双环杂环芳基化合物，该化合物在环的连接处可以含有一个桥接氮原子。该发明还提供了合成该发明化合物的方法、药物组合物、药物组合以及使用该发明化合物治疗病症的方法。