L-tert-Leucine-N-tert-butylamide trifluoroacetate salt | 171270-52-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-tert-Leucine-N-tert-butylamide trifluoroacetate salt
• 英文别名: (2S)-2-amino-N-tert-butyl-3,3-dimethylbutanamide;2,2,2-trifluoroacetic acid
• CAS: 171270-52-3
• 化学式: C₂HF₃O₂*C₁₀H₂₂N₂O
• 分子量: 300.321
• InChiKey: ZIEAMASSPUCFNO-OGFXRTJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.91
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP0740653B1

  公开（公告）日：1999-08-04
• US5861436A
  申请人：——

  公开号：US5861436A

  公开（公告）日：1999-01-19
• [EN] HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS<br/>[FR] DERIVES D'ACIDE HYDROXAMIQUE INHIBITEURS DE METALLOPROTEINASE
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：WO1995019957A1

  公开（公告）日：1995-07-27

  (EN) The following compounds: 2S-Hydroxy-3R-[1S-($i(tert)-butylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(N,N-dimethylcarbamoyl)-2,2-dimethyl-propyl-carbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(3-hydroxy-2,2-dimethylpropylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-6-phenyl-hexanohydroxamic acid and 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-butylcarbamoyl]-5-methyl-hexanohydroxamic acid are matrix metalloproteinase inhibitors.(FR) Les composés suivants: acide 2S-Hydroxy-3R[1S-$i(tert)-butylcarbamoyl)-2,2-diméthylpropylcarbamoyl]-5-méthyl-hexanohydroxamique, acide 2S-Hydroxy-3R-[1S-(N,N-diméthylcarbamoyl)-2,2-diméthyl-propyl-carbamoyl]-5-méthyl-hexanohydroxamique, acide 2s-Hydroxy-3R-[1S-(3-hydroxy-2,2-diméthylpropylcarbamoyl)-2,2-diméthyl-propylcarbamoyl]-5-méthyl-hexanohydroxamique, acide 2S-Hydroxy-3R-[1S-(méthylcarbamoyl)-2,2-diméthyl-propylcarbamoyl]-6-phényl-hexanohydroxamique et acide 2S-Hydroxy-3R-[1S-(méthylcarbamoyl)-2,2-diméthyl-butylcarbamoyl]-5-méthyl-hexanohydroxamique sont des inhibiteurs de métalloprotéinase de matrice.