1-Methyl-1,2,3,3a,4,8b-hexahydro-indeno[1,2-b]pyrrole | 50553-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-Methyl-1,2,3,3a,4,8b-hexahydro-indeno[1,2-b]pyrrole
• 英文别名: 1-methyl-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole
• CAS: 50553-28-1
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: NVEUHIVZLXKWCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Inhibitors of biogenic amine transporters
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0790250A2

  公开（公告）日：1997-08-20

  The present invention provides a compound having the following structure The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.

  本发明提供了一种具有以下结构的化合物 本发明还提供了一种药物组合物，其包含上述化合物和一种药学上可接受的载体。本发明进一步提供了一种治疗以多巴胺缺乏为特征的疾病的方法，该方法包括向需要治疗的受试者施用一定量的上述药物组合物以有效治疗该疾病。
• INHIBITORS OF BIOGENIC AMINE TRANSPORTERS
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0713484A1

  公开（公告）日：1996-05-29
• S1P1 AGONIST AND APPLICATION THEREOF
  申请人：Shijiazhuang Sagacity New Drug Development Co., Ltd.

  公开号：EP3492465B1

  公开（公告）日：2021-03-24
• US5574060A
  申请人：——

  公开号：US5574060A

  公开（公告）日：1996-11-12
• US5747503A
  申请人：——

  公开号：US5747503A

  公开（公告）日：1998-05-05