3-Methyl-N-(phenylcarbamoyl)-L-valine | 827612-22-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Methyl-N-(phenylcarbamoyl)-L-valine
• 英文别名: (2S)-3,3-dimethyl-2-(phenylcarbamoylamino)butanoic acid
• CAS: 827612-22-6
• 化学式: C₁₃H₁₈N₂O₃
• 分子量: 250.29
• InChiKey: ISCLPPSUXSPKQD-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• PROCESS FOR PRODUCTION OF N-CARBAMOYL-TERT-LEUCINE
  申请人：Kaneka Corporation

  公开号：EP2221294A1

  公开（公告）日：2010-08-25

  The present invention relates to a process for producing an N-carbamoyl-tert-leucine, characterized in mixing tert-leucine with an isocyanic acid compound while a pH of the mixture is kept at not less than 8.0 and not more than 13.5, wherein an amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to an amount of the tert-leucine. According to the present invention, it becomes possible to easily produce an N-carbamoyl-tert-leucine with high efficiency, while the generation of by-products such as a dipeptide-like compound and a urea compound is prevented.

  本发明涉及一种生产N-氨基甲酰基叔亮氨酸的工艺，其特征在于将叔亮氨酸与异氰酸化合物混合，同时将混合物的pH值保持在不低于8.0且不高于13.5，其中异氰酸化合物的量相对于叔亮氨酸的量不低于0.9倍摩尔且不高于1.1倍摩尔。根据本发明，可以很容易地高效生产出 N-氨基甲酰基叔亮氨酸，同时防止产生二肽类化合物和尿素化合物等副产物。
• US8183408B2
  申请人：——

  公开号：US8183408B2

  公开（公告）日：2012-05-22