2-amino-3-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid | 39846-91-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-3-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid
• 英文别名: β-(4-Oxy-3-methoxy-phenyl)-serin；α-Amino-β-oxy-β-(4-oxy-3-methoxy-phenyl)-propionsaeure；2-Amino-3-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propionsaeure；α-Amino-β-(4-oxy-3-methoxy-phenyl)-hydracrylsaeure；2-Amino-3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
• CAS: 39846-91-8
• 化学式: C₁₀H₁₃NO₅
• 分子量: 227.217
• InChiKey: WSTUOPKRORLDCX-UHFFFAOYSA-N

物化性质

• 沸点：
  488.4±45.0 °C(Predicted)
• 密度：
  1.436±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-amino-3-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid 、 氯甲酸苄酯 生成 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-(phenylmethoxycarbonylamino)propanoic acid
  参考文献：
  名称：

  OXASI, NAOXITO;NAGATA, AKIDZI;ISIDZUMI, KIKUO

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 sodium 作用下， 生成 2-amino-3-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid
  参考文献：
  名称：

  Rosenmund; Dornsaft, Chemische Berichte, 1919, vol. 52, p. 1742

  摘要：

  DOI：

文献信息

• Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them
  申请人：——

  公开号：US20020013312A1

  公开（公告）日：2002-01-31

  Norepinephrine uptake 2 inhibitors (or their precursors) are administered to enhance the effect of norepinephrine reuptake inhibitors and other antidepressants. The uptake 2 inhibitor may be combined in a single medication with a norepinephrine reuptake inhibitor, such as imipramine, desipramine, or reboxetine, in order to inhibit both uptake mechanisms. The norepinephrine uptake 2 inhibitors may also be combined with MAO inhibitors or with selective serotonin reuptake inhibitors. Alternatively, the norepinephrine uptake 2 inhibitors may be useful antidepressants in their own right, without the need for co-administration of other antidepressants. One class of norepinephrine uptake 2 inhibitors is normetanephrine (the O-methylated metabolite of norepinephrine) and normetanephrine precursors [such as 3-(4-hydroxy-3-methoxyphenyl)-serine (4H-3MePS ), particularly L-threo-3-(4-H-3MePS)]that are transported to the brain where they are converted into normethanephrine, thereby enhancing the effect of other antidepressants. For example, the invention enhances the antidepressant effect of norepinephrine reuptake inhibitors.

  去甲肾上腺素摄取 2 抑制剂（或其前体）用于增强去甲肾上腺素再摄取抑制剂和其他抗抑郁药的效果。摄取 2 抑制剂可与去甲肾上腺素再摄取抑制剂（如丙咪嗪、地西帕明或雷贝西汀）合用一种药物，以抑制两种摄取机制。去甲肾上腺素摄取 2 抑制剂还可与 MAO 抑制剂或选择性血清素再摄取抑制剂结合使用。另外，去甲肾上腺素摄取 2 抑制剂本身也是一种有用的抗抑郁药，无需同时使用其他抗抑郁药。去甲肾上腺素摄取 2 抑制剂中的一类是去甲肾上腺素 O-甲基化代谢产物去甲肾上腺素和去甲肾上腺素前体，如 3-(4-羟基)去甲肾上腺素；如 3-（4-羟基-3-甲氧基苯基）-丝氨酸（4H-3MePS），特别是 L-苏-3-（4-H-3MePS）]，它们被输送到大脑，在那里转化为去甲肾上腺素，从而增强其他抗抑郁药的效果。例如，本发明可增强去甲肾上腺素再摄取抑制剂的抗抑郁效果。
• Methods for the Treatment of ADHD and Related Disorders
  申请人：Teicher Martin

  公开号：US20090221552A1

  公开（公告）日：2009-09-03

  The invention features methods, compositions, and kits for the treatment of attention deficit hyperactivity disorder and related behavioral disorders by administering an organic cation 3 (hOCT3) inhibitor.
• [EN] THERAPEUTICS FOR TREATMENT RESISTANT MENTAL DISORDERS<br/>[FR] THÉRAPIE APPLICABLE AUX TROUBLES MENTAUX RÉSISTANTS AUX TRAITEMENTS
  申请人：UNIV TEXAS

  公开号：WO2009134877A2

  公开（公告）日：2009-11-05

  Described herein are treatments for patients suffering from a mental disorders that include administering an effective amount of an alkylamine-catechol derivative, a quinoline derivative, a bis-quinoline derivative, or combinations thereof.