L-Alanine,N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]- | 592543-24-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Alanine,N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-
• 英文别名: (2S)-2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]propanoic acid
• CAS: 592543-24-3
• 化学式: C₂₂H₂₇NO₈S
• 分子量: 465.5
• InChiKey: KLFKGEAXNPYTKB-VFNNOXKTSA-N

物化性质

• 沸点：
  752.7±60.0 °C(Predicted)
• 密度：
  1.309±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
  申请人：Reddy E. Premkumar

  公开号：US20100305059A1

  公开（公告）日：2010-12-02

  Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R 1 is selected from the group consisting of —NH 2 , —NH—CH 2 —CO 2 H, —NH—CH(CH 3 )—CO 2 H, and —NH—C(CH 3 ) 2 —CO 2 H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.

  提供了用于治疗骨髓增生异常综合征和急性髓系白血病的方法和组合物，其中该组合物包括至少一种符合以下式I的化合物：其中R1选自—NH2、—NH—CH2—CO2H、—NH—CH(CH3)—CO2H和—NH—C( )2—CO2H的群组，或者该化合物的药用可接受盐；以及DNA 甲基转移酶抑制剂，或其药用可接受盐。
• Composition and Methods For the Treatment of Proliferative Diseases
  申请人：Reddy E. Premkumar

  公开号：US20080161252A1

  公开（公告）日：2008-07-03

  Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R 1 is selected from the group consisting of —OH, —NH 2 , —NH—CH 2 —CO 2 H, —NH—CH(CH 3 )—CO 2 H, and —NH—C(CH 3 ) 2 —CO 2 H, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.

  提供了用于治疗增生性疾病的方法和组合物，其中该组合物包含至少一种符合式I的化合物，其中R1选自以下群体：—OH，—NH2，—NH—CH2—CO2H，—NH—CH（CH3）—CO2H和—NH—C（ ）2—CO2H，或该化合物的药学上可接受的盐；以及蒽环类化合物，例如多柔比星或其药学上可接受的盐，或铂类化合物，例如奥沙利铂或其药学上可接受的盐。
• TREATMENT OF DRUG-RESISTANT PROLIFERATIVE DISORDERS
  申请人：Temple University - Of The Commonwealth System of Higher Education

  公开号：EP1841420B1

  公开（公告）日：2011-12-07
• Treatment of Drug-Resistant Proliferative Disorders
  申请人：Reddy M. V. Ramana

  公开号：US20090306207A1

  公开（公告）日：2009-12-10

  α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competitive kinase inhibitors.
• US8106033B2
  申请人：——

  公开号：US8106033B2

  公开（公告）日：2012-01-31