(4R,5S)-4-methyl-5-propyl-1,3-oxazolidin-2-one | 1050654-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4R,5S)-4-methyl-5-propyl-1,3-oxazolidin-2-one
• CAS: 1050654-90-4
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: ARWHUVQKBDVREL-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dibenzyl 1-((2R,3S)-3-hydroxyhex-5-en-2-yl)hydrazine-1,2-dicarboxylate 在 palladium on activated charcoal potassium carbonate 、 氢气 、 盐酸 、 sodium nitrite 作用下， 以 溶剂黄146 为溶剂， 生成 (4R,5S)-4-methyl-5-propyl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Organocatalytic α-amination–allylation-RCM strategy: enantioselective synthesis of cyclic hydrazines

  摘要：

  A highly enantioselective method for the synthesis of cyclic hydrazines by using organocatalytic alpha-amination-allylation-RCM strategy is described. Proline-catalyzed alpha-amination of aldehydes followed by indium-mediated one-pot allylation of the crude alpha-hydrazino aldehydes produces 1,2-aminoalcohols in high enantio- and diastereoselectivities. The 1,2-aminoalcohols are further converted into cyclic hydrazines by using ring-closing metathesis (RCM) reaction. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.004

文献信息

• Organocatalytic α-amination–allylation-RCM strategy: enantioselective synthesis of cyclic hydrazines
  作者：Aram Lim、Jung Hoon Choi、Jinsung Tae

  DOI：10.1016/j.tetlet.2008.06.004

  日期：2008.8

  A highly enantioselective method for the synthesis of cyclic hydrazines by using organocatalytic alpha-amination-allylation-RCM strategy is described. Proline-catalyzed alpha-amination of aldehydes followed by indium-mediated one-pot allylation of the crude alpha-hydrazino aldehydes produces 1,2-aminoalcohols in high enantio- and diastereoselectivities. The 1,2-aminoalcohols are further converted into cyclic hydrazines by using ring-closing metathesis (RCM) reaction. (C) 2008 Elsevier Ltd. All rights reserved.