5,6-Dimethyl-3-nitropyridine-2-carbonitrile | 1314976-43-6

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 5,6-Dimethyl-3-nitropyridine-2-carbonitrile
• CAS: 1314976-43-6
• 化学式: C8H7N3O2
• mdl: MFCD08062823
• 分子量: 177.16
• InChiKey: ZRVMNHCFIMPNOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  82.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS
  申请人：Exelixis, Inc.

  公开号：EP3743068A1

  公开（公告）日：2020-12-02
• Compounds for the Treatment of Kinase-Dependent Disorders
  申请人：Exellxis, Inc.

  公开号：US20210040099A1

  公开（公告）日：2021-02-11

  Disclosed herein are compounds of Formula (I′). Compounds of Formula (I′) inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
• [EN] COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS<br/>[FR] COMPOSÉS DESTINÉS AU TRAITEMENT DES TROUBLES KINASES-DÉPENDANTS
  申请人：EXELIXIS INC

  公开号：WO2019148036A1

  公开（公告）日：2019-08-01

  Disclosed herein are compounds of Formula (I'). Compounds of Formula (I') inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.