(3S,4S)-4-amino-3-hydroxy-6-(methylsulfanyl)hexanoic acid | 300582-88-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,4S)-4-amino-3-hydroxy-6-(methylsulfanyl)hexanoic acid
• 英文别名: (3S,4S)-4-amino-3-hydroxy-6-methylsulfanylhexanoic acid
• CAS: 300582-88-1
• 化学式: C₇H₁₅NO₃S
• 分子量: 193.27
• InChiKey: WISWCUMXFLIPIS-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PEPTIDES<br/>[FR] PEPTIDES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016083425A1

  公开（公告）日：2016-06-02

  The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

  本发明涉及双位点BACE1抑制剂，它们的制造，含有它们的药物组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防治疗例如阿尔茨海默病方面是有用的。
• Peptides
  申请人：Hoffmann-La Roche Inc.

  公开号：US10208087B2

  公开（公告）日：2019-02-19

  The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

  本发明涉及双位点 BACE1 抑制剂、其制造、含有它们的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用于阿尔茨海默病等疾病的治疗和/或预防。
• Dual-site BACE1 inhibitors
  申请人：Hoffmann-La Roche Inc.

  公开号：US10683329B2

  公开（公告）日：2020-06-16

  Provided herein are peptides having dual-site BACE1 inhibitory activity, useful for the treatment of, for example Alzheimer's disease and diabetes. One such peptide is a dual-site BACE1 inhibitor, or a pharmaceutically acceptable salt thereof, binding to both an enzymatic active site and an catalytic domain of the BACE enzyme, and an exosite inhibitory part is connected to an active-site inhibitory part of the dual site BACE1 inhibitor by a linker.

  本文提供的多肽具有双位点 BACE1 抑制活性，可用于治疗阿尔茨海默病和糖尿病等疾病。其中一种多肽是双位点 BACE1 抑制剂或其药学上可接受的盐，可与 BACE 酶的酶活性位点和催化结构域结合，外抑制部分通过连接子与双位点 BACE1 抑制剂的活性位点抑制部分连接。
• BACE1 inhibitor peptides
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US10947272B2

  公开（公告）日：2021-03-16

  The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

  本发明涉及双位点 BACE1 抑制剂、其制造、含有它们的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用于阿尔茨海默病等疾病的治疗和/或预防。
• PEPTIDES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3224271A1

  公开（公告）日：2017-10-04