4-(2-iodophenoxy)butan-1-ol | 957040-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-iodophenoxy)butan-1-ol
• CAS: 957040-11-8
• 化学式: C₁₀H₁₃IO₂
• 分子量: 292.117
• InChiKey: PBWFPWJXXMHAIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘苯酚 在 水 、 dimethyl sulfide borane 、 potassium carbonate 、 lithium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 4-(2-iodophenoxy)butan-1-ol
  参考文献：
  名称：

  Development of new recyclable reagents and catalytic systems based on hypervalent iodine compounds

  摘要：

  Recent advances in the development of polymer-supported iodine(V) oxidants, recyclable monomeric hypervalent iodine(III) reagents and catalytic systems based on hypervalent iodine compounds are discussed. These efficient and environmentally friendly reagents and catalysts are particularly useful for oxidative transformations of alcohols to carbonyl compounds and for oxidations at the benzylic position.

  DOI：

  10.1016/j.mencom.2010.06.001

文献信息

• Preparation and Reactivity of Polymer-Supported 2-Iodylphenol Ethers, an Efficient Recyclable Oxidizing System
  作者：Rashad R. Karimov、Zeinul-Gabiden M. Kazhkenov、Matthew J. Modjewski、Eric M. Peterson、Viktor V. Zhdankin

  DOI：10.1021/jo7015746

  日期：2007.10.1

  [GRAPHICS]Preparation of new recyclable polymer-supported oxidizing reagents based on 2-iodylphenol ethers is described. The synthesis employs commercially available aminomethylated polystyrene or Merrifield resin and affords polymer-supported 2-iodylphenol ethers with loading up to 0.86 mmol/g with respect to 102 groups. The new reagents effect clean and efficient conversion of a wide range of alcohols, including heteroatomic and unsaturated structures, to the corresponding carbonyl compounds. Recycling of the resins is possible with minimal loss of activity after several reoxidations.
• [EN] PROCESS FOR PREPARING CYCLIC CHIRAL AMINES AND ALCOHOLS BY INTRAMOLECULAR CATALYTIC ARYLATION OF BORONIC ACID OR ESTER ALDEHYDES AND IMINE SUBSTRATES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'AMINES ET D'ALCOOLS CHIRAUX CYCLIQUES PAR ARYLATION CATALYTIQUE INTRAMOLÉCULAIRE DE SUBSTRATS D'ACIDE BORONIQUE, D'ESTER ALDÉHYDES ET D'IMINE
  申请人：UNIV ÉVORA

  公开号：WO2015033261A1

  公开（公告）日：2015-03-12

  The present application provides a catalytic process which involves the cyclization of a novel catalytic intramolecular arylation process that involves boronic acid or ester aldehydes or imines substrates, of formula (I) and (II), to afford cyclic chiral alcohols or amines, of formula (VI) and (VII), respectably. The present application also describes the preparation of the substrates of formula (I) and (II) from simple commercial raw materials by efficient processes, some of which are catalytic.