(Z)-1-benzyl-4-(N-methyl-N-(3-(propen-1-yl)-2-pyridinyl)amino)piperidine | 179556-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (Z)-1-benzyl-4-(N-methyl-N-(3-(propen-1-yl)-2-pyridinyl)amino)piperidine
• 英文别名: 1-benzyl-4-[N-methyl-N-(3-(1-propenyl)-2-pyridinyl)amino]piperidine；N-(1-benzylpiperidin-4-yl)-N-methyl-3-[(Z)-prop-1-enyl]pyridin-2-amine
• CAS: 179556-27-5
• 化学式: C₂₁H₂₇N₃
• 分子量: 321.465
• InChiKey: HTRQPUBOBZLUTP-BAQGIRSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  palladium dihydroxide 、 吡咯-2-羧酸 、 (Z)-1-benzyl-4-(N-methyl-N-(3-(propen-1-yl)-2-pyridinyl)amino)piperidine 在 CDI 作用下， 生成 1-[pyrrole-2-carbonyl]-4-[N-methyl-N-(3-(propyl)-2-pyridinyl)amino]piperidine
  参考文献：
  名称：

  Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds

  摘要：

  化合物的抗艾滋病公式（I）##STR1##其中R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5、R.sub.6和R.sub.7如规范中定义，R.sub.8是取代烷基的烷基。

  公开号：

  US05866589A1
• 作为产物：
  描述：

  2-溴-3-吡啶甲醛 在 正丁基锂 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 49.25h， 生成 (Z)-1-benzyl-4-(N-methyl-N-(3-(propen-1-yl)-2-pyridinyl)amino)piperidine
  参考文献：
  名称：

  Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors:  Effect of 3-Alkylpyridine Ring Substitution

  摘要：

  Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of activity of the (alkyl amino)piperidine containing bis(heteroaryl)piperazine (AAP-BHAP) class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis of analogues in which the usual 3-alkylamino substituent on the pyridine ring is replaced by a 3-alkyl substituent led to compounds which retained activity against recombinant P236L and wild-type (WT) reverse transcriptase (RT), while inhibition of the Y181C mutant RT was reduced relative to the activity of the 3-alkylamino-substituted congeners. Testing of representative analogues in an in vitro liver microsome assay indicated that the alkyl substituent would not appreciably improve the metabolic stability of the AAP-BHAP template. In vivo pharmacokinetic evaluation of three compounds confirmed these results in that high systemic clearances were observed. Nevertheless, one compound (13), PNU-103657, possessed oral bioavailability in rats approaching that of the structurally related NNRTI drug delavirdine which is currently on the market for the treatment of HIV infection.

  DOI：

  10.1021/jm990051a