I(2)-Amino-3-fluoro-4-methoxybenzeneethanol | 1094627-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: I(2)-Amino-3-fluoro-4-methoxybenzeneethanol
• 英文别名: 2-amino-2-(3-fluoro-4-methoxyphenyl)ethanol
• CAS: 1094627-42-5
• 化学式: C₉H₁₂FNO₂
• 分子量: 185.2
• InChiKey: WLYGTWXVCBIYEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SERINE/THREONINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE!DISEASES
  申请人：Array Biopharma, Inc.

  公开号：EP2888247A1

  公开（公告）日：2015-07-01
• SERINE/THREONINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
  申请人：Array Biopharma, Inc.

  公开号：EP2888247B1

  公开（公告）日：2020-03-25
• BRIDGED PYRAZOLOPYRIDINE DERIVATIVES AS ERK INHIBITORS USEFUL FOR THE TREATEMENT OF CANCER
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3233859B1

  公开（公告）日：2019-08-07
• ERK INHIBITORS
  申请人：Siliphaivanh Phieng

  公开号：US20170267695A1

  公开（公告）日：2017-09-21

  The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).
• US9988397B2
  申请人：——

  公开号：US9988397B2

  公开（公告）日：2018-06-05