2-(2-Bromo-cyclohex-1-enylmethyl)-2-((Z)-4-hydroxy-2-methyl-but-2-enyl)-malonic acid dimethyl ester | 138036-70-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(2-Bromo-cyclohex-1-enylmethyl)-2-((Z)-4-hydroxy-2-methyl-but-2-enyl)-malonic acid dimethyl ester
• CAS: 138036-70-1
• 化学式: C₁₇H₂₅BrO₅
• 分子量: 389.286
• InChiKey: YWEGIFMONZUKAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  461.1±45.0 °C(Predicted)
• 密度：
  1.323±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  2-(2-Bromo-cyclohex-1-enylmethyl)-2-((Z)-4-hydroxy-2-methyl-but-2-enyl)-malonic acid dimethyl ester 在 palladium diacetate 、 三苯基膦 三乙胺 作用下， 以 乙腈 为溶剂， 反应 36.0h， 以52%的产率得到4-Methyl-4-(2-oxo-ethyl)-3,4,5,6,7,8-hexahydro-1H-naphthalene-2,2-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  Intramolecular Heck reaction with substrates possessing an allylic alcohol moiety

  摘要：

  In this paper we report our investigation on a series of palladium catalysed cyclisations with substrates possessing an allylic alcohol moiety. This methodology provides a good approach to a wide variety of functionalised 5 or 6 membered carbo- or heterocycles. We also demonstrate that it is possible to combine an alkylation and a cyclisation process using the same palladium catalyst system.

  DOI：

  10.1016/0040-4039(91)80766-y