| 1055204-19-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1055204-19-7
• 化学式: C₁₁H₁₄FN₃O₃S
• 分子量: 287.315
• InChiKey: PSVZGMHKEBRYOX-MRTMQBJTSA-N

反应信息

• 作为反应物：
  描述：

  在 甲醇 、 氨 作用下， 生成 4-amino-1-[(3S,4S,5R)-4-fluoro-5-(hydroxymethyl)thiolan-3-yl]pyrimidin-2-one
  参考文献：
  名称：

  Design, Enantiopure Synthesis, and Biological Evaluation of Novel ISO-D-2′,3′-Dideoxy-3′-Fluorothianucleoside Derivatives as a bioisostere of Lamivudine

  摘要：

  Novel isoD-2',3'-dideoxythianucleoside derivatives 1-3 were designed and asymmetrically synthesized to search for new anti-HIV agents. Final compounds 1-3 were evaluated against a variety of viruses including HIV-1 and 2. Only cytosine analog 3 showed a potent anti-VSV activity (EC50 = 9.43 mu g/mL). This result implies that iso 2',3'-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.

  DOI：

  10.1080/15257770701506426
• 作为产物：
  描述：

  在 ammonium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Design, Enantiopure Synthesis, and Biological Evaluation of Novel ISO-D-2′,3′-Dideoxy-3′-Fluorothianucleoside Derivatives as a bioisostere of Lamivudine

  摘要：

  Novel isoD-2',3'-dideoxythianucleoside derivatives 1-3 were designed and asymmetrically synthesized to search for new anti-HIV agents. Final compounds 1-3 were evaluated against a variety of viruses including HIV-1 and 2. Only cytosine analog 3 showed a potent anti-VSV activity (EC50 = 9.43 mu g/mL). This result implies that iso 2',3'-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.

  DOI：

  10.1080/15257770701506426