H-α-Glu-Ser-Tau-OH | 119292-32-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-α-Glu-Ser-Tau-OH
• 英文别名: (4S)-4-amino-5-[[(2S)-3-hydroxy-1-oxo-1-(2-sulfoethylamino)propan-2-yl]amino]-5-oxopentanoic acid
• CAS: 119292-32-9
• 化学式: C₁₀H₁₉N₃O₈S
• 分子量: 341.342
• InChiKey: JDGVERPEPWVLMT-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.34
• 重原子数：
  22.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  196.12
• 氢给体数：
  6.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  sodium;2-[[(2S)-3-hydroxy-2-[[(2S)-5-oxo-5-phenylmethoxy-2-(phenylmethoxycarbonylamino)pentanoyl]amino]propanoyl]amino]ethanesulfonate 以66%的产率得到
  参考文献：
  名称：

  IENAGA, KAZUHARU;NAKAMURA, KO;HIGASHIURA, KUNIHIKO;TOYOMAKI, YOSHIO;KIMUR+, CHEM. AND PHARM. BULL., 36,(1988) N 8, C. 2796-2801

  摘要：

  DOI：

文献信息

• Simple peptides. III. Syntheses and properties of taurine-oligopeptides containing an acidic .ALPHA.-amino acid.
  作者：KAZUHARU IENAGA、KO NAKAMURA、KUNIHIKO HIGASHIURA、YOSHIO TOYOMAKI、HIROSHI KIMURA

  DOI：10.1248/cpb.36.2796

  日期：——

  Although taurine-dipeptides containing an acidic α-amino acid (Glu or Asp) have been proposed to exist in the central nervous system, it is not yet clear how the acidic amino acid is linked with taurine in the peptides. This study aimed to analyze the mode of linkage of such peptides through analysis of their spectral data, such as proton nuclear magnetic resonance and mass spectra. Four pairs of taurine-oligopeptides (1-8) containing one acidic α-amino acid were examined, and spattered ion mass spectrometry B/E linked scan mass spectrometry was proved to be most useful to distinguish each pair of isomers. Further, immunochemical examination indiated that all the oligopeptides (1-8) synthesized by the conventional coupling method were highly cross-reactive with antisera against taurine and against γGlu-Tau.

  尽管已有提议认为中枢神经系统中存在含有酸性α-氨基酸（Glu或Asp）的牛磺酸二肽，但目前尚不清楚这种酸性氨基酸是如何与牛磺酸在肽中相连的。本研究旨在通过分析其光谱数据，如质子核磁共振和质谱，来探讨这类肽的连接模式。我们检查了四对含有一个酸性α-氨基酸的牛磺酸寡肽（1-8），并证明喷雾离子质谱B/E链扫描质谱法在区分每一对异构体时最为有效。进一步的免疫化学检验表明，通过常规偶联方法合成的所有寡肽（1-8）均与针对牛磺酸和γGlu-Tau的抗血清高度交叉反应。