3-Amino-4,6-dimethyl-selenolo[2,3-b]pyridine-2-carboxylic acid hydrazide | 935469-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Amino-4,6-dimethyl-selenolo[2,3-b]pyridine-2-carboxylic acid hydrazide
• CAS: 935469-97-9
• 化学式: C₁₀H₁₂N₄OSe
• 分子量: 283.191
• InChiKey: WPBRHWSYQKIWOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.09
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.03
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-Amino-4,6-dimethyl-selenolo[2,3-b]pyridine-2-carboxylic acid hydrazide 在 哌啶 、 吡啶 作用下， 以 乙醇 为溶剂， 反应 75.0h， 生成
  参考文献：
  名称：

  Selenium-Containing Heterocycles: Synthetic Investigation of 3-Amino-2-Ethylselenopyridine Carboxylate Using Sodium Borohydride

  摘要：

  3-amino-4,6-dimethyl-2-ethylseleno[2,3-b]pyridine carboxylate (5) was prepared by a reaction of dipyridyl diselenide derivative (3) with sodium borohydride as a reducing agent followed by alpha-haloester. The reaction of 5 with hydrazine hydrate afforded the corresponding carbohydrazide 8. The benzylidene derivative 9 provided novel heterocycles of pyrimidoseleno pyridine and thiazinoseleno pyridine derivatives (10-12), upon treatment with triethylorthoformate, acetic anhydride, and carbon disulfide, respectively.

  DOI：

  10.1080/10426500600616795
• 作为产物：
  描述：

  ethyl 3-amino-4,6-dimethyl selenolo[2,3-b]pyridine-2-carboxylate 在 一水合肼 作用下， 反应 5.0h， 以84%的产率得到3-Amino-4,6-dimethyl-selenolo[2,3-b]pyridine-2-carboxylic acid hydrazide
  参考文献：
  名称：

  Selenium-Containing Heterocycles: Synthetic Investigation of 3-Amino-2-Ethylselenopyridine Carboxylate Using Sodium Borohydride

  摘要：

  3-amino-4,6-dimethyl-2-ethylseleno[2,3-b]pyridine carboxylate (5) was prepared by a reaction of dipyridyl diselenide derivative (3) with sodium borohydride as a reducing agent followed by alpha-haloester. The reaction of 5 with hydrazine hydrate afforded the corresponding carbohydrazide 8. The benzylidene derivative 9 provided novel heterocycles of pyrimidoseleno pyridine and thiazinoseleno pyridine derivatives (10-12), upon treatment with triethylorthoformate, acetic anhydride, and carbon disulfide, respectively.

  DOI：

  10.1080/10426500600616795