4-Hydroxy-pyridon-(2)-carbonsaeure-(6) | 27347-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Hydroxy-pyridon-(2)-carbonsaeure-(6)
• 英文别名: 4,6-dihydroxy-pyridine-2-carboxylic acid；4,6-Dihydroxy-pyridin-2-carbonsaeure；4,6-Dihydroxypyridine-2-carboxylic acid；4-hydroxy-6-oxo-1H-pyridine-2-carboxylic acid
• CAS: 27347-88-2
• 化学式: C₆H₅NO₄
• mdl: MFCD20640582
• 分子量: 155.11
• InChiKey: XLVJKDXPBUHZLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-pyridon-(2)-carbonsaeure-(6) 在 重氮甲烷 、 乙醚 作用下， 生成 methyl 4-methoxy-1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate
  参考文献：
  名称：

  Stetter; Schellhammer, Chemische Berichte, 1957, vol. 90, p. 755,757

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ammonium hydroxide 作用下， 生成 4-Hydroxy-pyridon-(2)-carbonsaeure-(6)
  参考文献：
  名称：

  Stetter; Schellhammer, Chemische Berichte, 1957, vol. 90, p. 755,757

  摘要：

  DOI：

文献信息

• Antimicrobial compounds and compositions, and uses thereof
  申请人：Akeso Biomedical, Inc.

  公开号：US10264766B2

  公开（公告）日：2019-04-23

  A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron center selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.

  提供了一种促进动物生长的方法。该方法包括使动物摄入或吸收有效量的一种或多种铁Ⅲ络合物，包括但不限于铁Ⅲ络合物，该络合物包含与铁中心结合的配体，这些配体选自氨基酸或α-羟基酸、邻羟基苯甲酸或吡啶-2-羧酸，例如奎宁酸铁、酪氨酸铁、DOPA铁和苯丙氨酸铁。本文还公开了前述化合物的结构和/或功能变体、衍生物和/或类似物。本发明还提供了抑制、减少或防止表面生物膜形成或堆积的方法；在生物和非生物环境中治疗、抑制细菌生长和抑制细菌定植的方法；消毒表面、增强抗生素和其他抗微生物剂的效果以及提高细菌和其他微生物对抗微生物剂的敏感性的方法。
• Sedgwick; Collie, Journal of the Chemical Society, 1895, vol. 67, p. 408
  作者：Sedgwick、Collie

  DOI：——

  日期：——
• ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
  申请人：Akeso Biomedical, Inc.

  公开号：US20160066578A1

  公开（公告）日：2016-03-10

  A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
• METAL CHELATES AND COMPOSITIONS COMPRISING METAL CHELATES AS NUTRITIONAL AND/OR ANTIMICROBIAL COMPOSITIONS FOR ADMINISTRATION TO ANIMALS
  申请人：Johnson Bruce

  公开号：US20190328004A1

  公开（公告）日：2019-10-31

  Disclosed herein are embodiments of a metal chelate, and compositions and/or combinations comprising the same. Also disclosed are embodiments of a method for making the metal chelate and a method for using the metal chelate. In some embodiments, the metal chelate is administered to an animal.
• US4171313A
  申请人：——

  公开号：US4171313A

  公开（公告）日：1979-10-16