L-Ascorbyl 2,6-Dibutyrate | 4337-04-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Ascorbyl 2,6-Dibutyrate
• 英文别名: [(2S)-2-[(2R)-4-butanoyloxy-3-hydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] butanoate
• CAS: 4337-04-6
• 化学式: C₁₄H₂₀O₈
• 分子量: 316.3
• InChiKey: BFXWCTCPRAYDEB-QPUJVOFHSA-N

物化性质

• 熔点：
  122 °C
• 溶解度：
  在EtOH中几乎透明
• LogP：
  -0.180 (est)
• 稳定性/保质期：
  在常温常压下保持稳定

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 海关编码：
  2932209090

文献信息

• Sustained release eye drop formulations
  申请人：Ramscor, Inc.

  公开号：US10744202B2

  公开（公告）日：2020-08-18

  This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.

  本发明提供了生物相容性、可生物降解的滴眼液药物制剂，可用于治疗眼部疾病。特别是，生育酚及其低水溶性酯类，尤其是 α-生育酚乙酸酯，是生物相容性、无刺激性、可持续释放活性剂的外用眼药水制剂的理想载体。
• Conveniently implantable sustained release drug compositions
  申请人：Wong G. Vernon

  公开号：US20080038316A1

  公开（公告）日：2008-02-14

  This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.
• SUSTAINED RELEASE EYE DROP FORMULATIONS
  申请人：WONG Vernon G.

  公开号：US20090136445A1

  公开（公告）日：2009-05-28

  This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.
• CONVENIENTLY IMPLANTABLE SUSTAINED RELEASE DRUG COMPOSITIONS
  申请人：WONG Vernon G.

  公开号：US20110111006A1

  公开（公告）日：2011-05-12

  This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.
• US8541413B2
  申请人：——

  公开号：US8541413B2

  公开（公告）日：2013-09-24

表征谱图