5-aminoimidazole-4-[(N-cyclohexyl)carboxamide] hydrochloride | 7254-00-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-aminoimidazole-4-[(N-cyclohexyl)carboxamide] hydrochloride
• 英文别名: 4-amino-N-cyclohexyl-1H-imidazole-5-carboxamide;hydrochloride
• CAS: 7254-00-4
• 化学式: C₁₀H₁₆N₄O*ClH
• 分子量: 244.724
• InChiKey: JBFFXLJKWOVFSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  83.8
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-aminoimidazole-4-[(N-cyclohexyl)carboxamide] hydrochloride 在 盐酸 、 sodium nitrite 作用下， 以77%的产率得到N-cyclohexyl-5-diazoimidazole-4-carboxamide
  参考文献：
  名称：

  摘要：

  Diazotization of 4-R-5-aminoimidazoles (R = CONHAr, CONHAlk, morphohnocarbonyl, or piperidinocarbonyl) with sodium nitrite in aqueous solutions of mineral acids afforded the corresponding 5-diazoimidazoles, whereas the reactions in concentrated tetrafluoroboric acid produced imidazolyl-5-diazonium salts. In the solid phase, diazonium salts are transformed into the corresponding diazo compounds.

  DOI：

  10.1023/a:1025605512301

文献信息

• ——
  作者：E. V. Sadchikova、V. S. Mokrushin

  DOI：10.1023/a:1025605512301

  日期：——

  Diazotization of 4-R-5-aminoimidazoles (R = CONHAr, CONHAlk, morphohnocarbonyl, or piperidinocarbonyl) with sodium nitrite in aqueous solutions of mineral acids afforded the corresponding 5-diazoimidazoles, whereas the reactions in concentrated tetrafluoroboric acid produced imidazolyl-5-diazonium salts. In the solid phase, diazonium salts are transformed into the corresponding diazo compounds.