2.4-Dimethyl-3-aethoxycarbonyl-thiophen | 36382-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2.4-Dimethyl-3-aethoxycarbonyl-thiophen
• 英文别名: 2,4-dimethyl-thiophene-3-carboxylic acid ethyl ester；Ethyl 2,4-dimethylthiophene-3-carboxylate
• CAS: 36382-81-7
• 化学式: C₉H₁₂O₂S
• 分子量: 184.259
• InChiKey: FWCQUEHDHGUPJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：INFINITY PHARMACEUTICALS, INC.

  公开号：US20130267521A1

  公开（公告）日：2013-10-10

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本发明描述了调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及用于治疗与激酶活性相关的疾病和状况的化合物、药物组合物和方法，包括PI3激酶活性。
• [EN] NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS ACC
  申请人：NANJING RUIJIE PHARMATECH CO LTD

  公开号：WO2019015583A1

  公开（公告）日：2019-01-24

  The present invention provides compounds of Formula (I) which can be used as ACC inhibitors and potently as therapeutic agents against diseases mediated by ACC.

  本发明提供了一种可以用作ACC抑制剂的Formula (I)化合物，可以作为治疗ACC介导的疾病的有效药物。
• [EN] HISTONE METHYLTRANSFERASE EZH2 INHIBITOR, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF<br/>[FR] INHIBITEUR D'HISTONE MÉTHYLTRANSFÉRASE EZH2, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION PHARMACEUTIQUE<br/>[ZH] 一种组蛋白甲基转移酶EZH2抑制剂、其制备方法及其医药用途
  申请人：ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD

  公开号：WO2018137639A1

  公开（公告）日：2018-08-02

  本发明涉及一种组蛋白甲基转移酶EZH2抑制剂、其制备方法及其医药用途。特别地，本发明涉及通式（I）所示的化合物，其制备方法及含有其的药物组合物，以及其作为组蛋白甲基转移酶EZH2抑制剂，治疗与组蛋白甲基转移酶EZH2相关的疾病特别是癌症的用途。其中通式（I）中的各取代基的定义与说明书中的定义相同。
• Isoquinoline derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070191423A1

  公开（公告）日：2007-08-16

  The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Benzimidazolyl derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070191444A1

  公开（公告）日：2007-08-16

  The present invention relates to benzimidazolyl derivatives of formula (I), with the definition of R 8 , p , Ar 1 , E, D, R 9 , q and R 10 according to claim 1 , the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.