Dimethyl 3,3'-(1,4-phenylenedioxy)bis(2,2,3,3-tetrafluoropropionate) | 131043-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Dimethyl 3,3'-(1,4-phenylenedioxy)bis(2,2,3,3-tetrafluoropropionate)
• 英文别名: Methyl 2,2,3,3-tetrafluoro-3-[4-(1,1,2,2-tetrafluoro-3-methoxy-3-oxopropoxy)phenoxy]propanoate
• CAS: 131043-15-7
• 化学式: C₁₄H₁₀F₈O₆
• 分子量: 426.217
• InChiKey: KJOPVPDSDLNBJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  Dimethyl 3,3'-(1,4-phenylenedioxy)bis(2,2,3,3-tetrafluoropropionate) 在 氨 作用下， 以 甲醇 为溶剂， 以89%的产率得到3,3'-(1,4-Phenylenedioxy)bis(2,2,3,3-tetrafluoropropanamide)
  参考文献：
  名称：

  Tandem nucleophilic additions of aryloxides

  摘要：

  Hydroquinone disodium salt added sequentially to tetrafluoroethylene and carbon dioxide to yield a symmetrical dicarboxylic acid, which was transformed into the corresponding dimethyl ester, diol, diamide, and diamine. Chlorotrifluoroethylene in analogous reactions gave the corresponding diester and diol in excellent yield. When this kind of transformation was attempted on phloroglucinol, the Kolbe-Schmitt carboxylation reaction intervened. Despite serious competition from addition/elimination processes under typical reaction conditions, the tandem addition of phenoxide ion to hexafluoropropene and carbon dioxide was carried out successfully at lower temperatures and higher carbon dioxide pressures.

  DOI：

  10.1021/jo00001a031
• 作为产物：
  描述：

  甲醇 、 3,3'-(1,4-Phenylenedioxy)bis(2,2,3,3-tetrafluoropropanoic acid) 在 硫酸 作用下， 以21.9 g的产率得到Dimethyl 3,3'-(1,4-phenylenedioxy)bis(2,2,3,3-tetrafluoropropionate)
  参考文献：
  名称：

  Tandem nucleophilic additions of aryloxides

  摘要：

  Hydroquinone disodium salt added sequentially to tetrafluoroethylene and carbon dioxide to yield a symmetrical dicarboxylic acid, which was transformed into the corresponding dimethyl ester, diol, diamide, and diamine. Chlorotrifluoroethylene in analogous reactions gave the corresponding diester and diol in excellent yield. When this kind of transformation was attempted on phloroglucinol, the Kolbe-Schmitt carboxylation reaction intervened. Despite serious competition from addition/elimination processes under typical reaction conditions, the tandem addition of phenoxide ion to hexafluoropropene and carbon dioxide was carried out successfully at lower temperatures and higher carbon dioxide pressures.

  DOI：

  10.1021/jo00001a031

文献信息

• ARNOLD-STANTON, REGINA;LEMAL, DAVID M., J. ORG. CHEM., 56,(1991) N, C. 151-157
  作者：ARNOLD-STANTON, REGINA、LEMAL, DAVID M.

  DOI：——

  日期：——