(2S,3S,5S,6S)-2-chloro-6-methyltetrahydro-2H-pyran-3,5-diyl dibenzoate | 210100-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3S,5S,6S)-2-chloro-6-methyltetrahydro-2H-pyran-3,5-diyl dibenzoate
• CAS: 210100-22-4
• 化学式: C₂₀H₁₉ClO₅
• 分子量: 374.821
• InChiKey: XWNNBFXGDONXKJ-XDKFSHSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (2S,3S,5S,6S)-2-chloro-6-methyltetrahydro-2H-pyran-3,5-diyl dibenzoate 在 palladium on activated charcoal sodium hydroxide 、 3 A molecular sieve 、 氢气 、 碳酸氢钠 、 silver carbonate 作用下， 以 乙醚 、 二氯甲烷 、 乙腈 为溶剂， 反应 22.0h， 生成 3-deoxy-L-fucose phosphate dilithium salt
  参考文献：
  名称：

  Chemical synthesis of GDP-l-galactose and analogues

  摘要：

  Succinct syntheses for L-galactose, 3-deoxy-L-xylo-hexose (3-deoxy-L-galactose), 6-deoxy-L-galactopyranose (L-fucose) and 3,6-dideoxy-L-xylo-hexose (3,6-dideoxy-L-galactose) have been developed starting from commercially available L-galactono-1,4-lactone. L-Galactose and variants were then converted to the guanosine diphosphate derivatives, via the formation of the anomeric phosphates and coupling to guanosine monophosphate morpholidate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(97)10094-5
• 作为产物：
  描述：

  Abequose 在 zinc(II) chloride 作用下， 以 吡啶 为溶剂， 反应 7.0h， 生成 (2S,3S,5S,6S)-2-chloro-6-methyltetrahydro-2H-pyran-3,5-diyl dibenzoate
  参考文献：
  名称：

  Chemical synthesis of GDP-l-galactose and analogues

  摘要：

  Succinct syntheses for L-galactose, 3-deoxy-L-xylo-hexose (3-deoxy-L-galactose), 6-deoxy-L-galactopyranose (L-fucose) and 3,6-dideoxy-L-xylo-hexose (3,6-dideoxy-L-galactose) have been developed starting from commercially available L-galactono-1,4-lactone. L-Galactose and variants were then converted to the guanosine diphosphate derivatives, via the formation of the anomeric phosphates and coupling to guanosine monophosphate morpholidate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(97)10094-5