2-[6-chloro-3-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-2-oxoimidazo[1,2-a]pyridin-3-yl]-N-(4-methoxyphenyl)acetamide | 1393664-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[6-chloro-3-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-2-oxoimidazo[1,2-a]pyridin-3-yl]-N-(4-methoxyphenyl)acetamide
• CAS: 1393664-42-0
• 化学式: C₂₇H₂₃ClN₄O₆
• 分子量: 534.956
• InChiKey: HKQAQPMSPOBMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-5-氯吡啶 、 1-(4-甲氧基苯基)-1H-吡咯-2,5-二酮 在 lithium perchlorate 作用下， 以 1,4-二氧六环 为溶剂， 以50%的产率得到2-[6-chloro-3-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-2-oxoimidazo[1,2-a]pyridin-3-yl]-N-(4-methoxyphenyl)acetamide
  参考文献：
  名称：

  Catalysis by Lithium Perchlorate Enables Double-Conjugate Addition of Electron-Deficient Maleimides to 2-Aminopyridines and 2-Aminothiazoles

  摘要：

  Lithium perchlorate has been found to catalyze the conjugate addition of maleimides with 2-aminopyridines and 2-aminothiazoles. The reaction proceeds under mild conditions leading to the corresponding double adducts in good yields. A plausible mechanism of this reaction has been proposed.

  DOI：

  10.1080/00397911.2011.580883

文献信息

• Catalysis by Lithium Perchlorate Enables Double-Conjugate Addition of Electron-Deficient Maleimides to 2-Aminopyridines and 2-Aminothiazoles
  作者：Tetiana Matviiuk、Marian Gorichko、Andriy Kysil、Svitlana Shishkina、Oleg Shishkin、Zoia Voitenko

  DOI：10.1080/00397911.2011.580883

  日期：2012.11.15

  Lithium perchlorate has been found to catalyze the conjugate addition of maleimides with 2-aminopyridines and 2-aminothiazoles. The reaction proceeds under mild conditions leading to the corresponding double adducts in good yields. A plausible mechanism of this reaction has been proposed.