p-Fluorphenyl-chlormethyl-ether | 34888-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-Fluorphenyl-chlormethyl-ether
• 英文别名: 1-(Chloromethoxy)-4-fluorobenzene
• CAS: 34888-02-3
• 化学式: C₇H₆ClFO
• 分子量: 160.575
• InChiKey: QTZCJQOFRVIAPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT
  申请人：THE UNIVERSITY OF KANSAS

  公开号：EP1786424A2

  公开（公告）日：2007-05-23
• LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT
  申请人：University Of Kansas

  公开号：EP2451783A2

  公开（公告）日：2012-05-16
• [EN] LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT<br/>[FR] ANALOGUES DE LONIDAMINE ET LEUR UTILISATION DANS LA CONTRACEPTION MASCULINE ET DANS LE TRAITEMENT DU CANCER
  申请人：UNIV KANSAS

  公开号：WO2006023704A2

  公开（公告）日：2006-03-02

  Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.
• [EN] LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT<br/>[FR] ANALOGUES DE LONIDAMIDE POUR UNE GESTION DE LA FERTILITÉ
  申请人：UNIV KANSAS

  公开号：WO2011005759A2

  公开（公告）日：2011-01-13

  Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.