7a-Hydroxy-5,7-dihydroisoindolo[2,1-a][4,1]benzothiazepin-12-one | 1334337-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7a-Hydroxy-5,7-dihydroisoindolo[2,1-a][4,1]benzothiazepin-12-one
• CAS: 1334337-01-7
• 化学式: C₁₆H₁₃NO₂S
• 分子量: 283.351
• InChiKey: YCBVTJFKXPYRAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[2-(Methylsulfanylmethyl)phenyl]isoindole-1,3-dione 以 丙酮 为溶剂， 反应 3.0h， 以35%的产率得到7a-Hydroxy-5,7-dihydroisoindolo[2,1-a][4,1]benzothiazepin-12-one
  参考文献：
  名称：

  Photoinduced electron transfer cyclizations of aryl-linked phthalimides

  摘要：

  The photochemistry photochemistry of arene-linked phthalimides incorporating the carboxylate or thioether donor group was investigated. Simple N-phthalimidophenyl alkanoates exclusively gave photoreduction (CO2H/H-exchange) products. In contrast, omega-phthalimido-meta-phenoxy carboxylates underwent photodecarboxylative cyclizations in yields of 6-48%. Likewise, catechol-linked derivatives furnished analogue cyclization products in 18-38% yield. Using the photodecarboxylation protocol, macrocyclic target compounds with ring sizes up to 17 could thus be realized. Two model phthalimides containing a thioether branch at the ortho-position of the arene-linker gave the analogue seven-membered cyclization products in yields of 28% and 35%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.069