Octadeca-11,13,15-trienoic acid | 25575-00-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Octadeca-11,13,15-trienoic acid
• CAS: 25575-00-2
• 化学式: C₁₈H₃₀O₂
• 分子量: 278.4
• InChiKey: ZSXWVPXJLXTOQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING<br/>[FR] COMPOSÉS À PETITES MOLÉCULES POUR FAVORISER UN VIEILLISSEMENT HUMAIN SAIN
  申请人：CARDAX PHARMA INC

  公开号：WO2018183353A1

  公开（公告）日：2018-10-04

  Disclosed herein are methods of activating expression of the FOXO3 gene in a subject comprising administering to a subject small molecule compound (such as astaxanthin and/or one or more astaxanthin derivatives), or pharmaceutically acceptable salts thereof, in an amount sufficient to at least partially increase the amount of FoxO3 expressed in the subject.

  本文揭示了一种激活主体中FOXO3基因表达的方法，包括向主体施用小分子化合物（如虾青素和/或一个或多个虾青素衍生物）或其药用可接受盐，以足够数量至少部分增加主体中表达的FoxO3的方法。
• SYNTHESIS OF CAROTENOID ANALOGS OR DERIVATIVES WITH IMPROVED ANTIOXIDANT CHARACTERISTICS
  申请人：Foss Bente J.

  公开号：US20090099061A1

  公开（公告）日：2009-04-16

  A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

  本文描述了一种合成和给予具有改善抗氧化特性的类胡萝卜素化合物的方法。在某些实施方式中，可以采用共轭的扩展或改进来进行类胡萝卜素的结构修饰。在其他实施方式中，降低环/链位阻可能会提高特定化合物的lambda max，从而提高其整体抗氧化能力。在其他实施方式中，引入和/或增加用于共轭的合成手柄可能会改善共轭基团与多烯骨架的化学计量比。这些方法可用于改善天然和/或合成化合物，以用于治疗疾病的医学应用。
• Ouabain like compounds and pharmaceutical compositions containing them
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

  公开号：EP0381527A1

  公开（公告）日：1990-08-08

  Compounds having digitalis-like activity are isolated from dried mammalian plasma. They may have the formula: wherein R1 represents a C1-6 straight or branched alkyl radical and n is an integer of from 2 to 11, and pharmaceutically acceptable salts thereof. or; wherein R represents an alkylenecarboxy, alkylenecarbonyloxy-alkyl, carbonyloxy-alkyl or alkyleneoxyalkylene-carbonyloxyalkyl radical.

  具有洋地黄样活性的化合物是从干燥的哺乳动物血浆中分离出来的。它们的化学式如下 其中 R1 代表 C1-6 直链或支链烷基，n 为 2 至 11 的整数，以及它们的药学上可接受的盐； 其中 R 代表亚烷基羧基、亚烷基羰氧基烷基、羰氧基烷基或亚烷氧基烷基羰氧基烷基。
• Nutraceutical composition and methods of use
  申请人：Dacy Tech Party Ltd.

  公开号：US10376550B2

  公开（公告）日：2019-08-13

  A method of modulating inflammation in an organism, which includes administering to an organism a composition including a therapeutic amount of a hydrolyzed extract from the plant Biota orientalis. Several key components of the hydrolyzed extract of Biota orientalis have been identified that have also been shown to have an effect in dramatically reducing inflammatory responses.

  一种调节生物体内炎症的方法，包括向生物体施用一种组合物，该组合物包括治疗量的东方曙红植物水解提取物。已确定东方糙叶榕水解提取物中的几种关键成分也被证明具有显著降低炎症反应的作用。
• System and methods for making bioproducts
  申请人：Benefuel, Inc.

  公开号：US10590061B2

  公开（公告）日：2020-03-17

  Processes for continuous preparation of bioproducts are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of an acidic heterogeneous catalyst and separating the fatty acid alkyl esters from the reaction products.

  本文描述了连续制备生物产品的工艺。该工艺包括在酸性异相催化剂存在下将脂肪酸甘油酯与醇类接触，并从反应产物中分离脂肪酸烷基酯。