18-Aminooctadec-9-enoic acid | 208988-74-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 18-Aminooctadec-9-enoic acid
• CAS: 208988-74-3
• 化学式: C₁₈H₃₅NO₂
• 分子量: 297.5
• InChiKey: YZAKXZHVVYVUAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Albumin-Binding Conjugates Comprising a Fatty Acid and Peg
  申请人：Eaton Anthony William Michael

  公开号：US20080096957A1

  公开（公告）日：2008-04-24

  The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

  本发明提供了一种基本由以下元素组成的白蛋白结合化合物：一个空间群、一个水溶性桥接群、一个脂肪酸链和一个酸性基团，其特征在于酸性基团附着在脂肪酸链的远端。该发明还提供了一种附有一种或多种生物活性物质的白蛋白结合化合物。
• ApoE mimetic peptides and higher potency to clear plasma cholesterol
  申请人：UAB RESEARCH FOUNDATION

  公开号：US10653747B2

  公开（公告）日：2020-05-19

  Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明公开了可用作降低血浆胆固醇的治疗剂的合成载脂蛋白E模拟肽、其衍生物和相关肽；制造这些肽的合成方法；包含这些肽的药物组合物，以及使用所公开的合成载脂蛋白E模拟肽及其组合物治疗脂质和代谢紊乱的方法。本摘要旨在作为在特定技术领域进行检索的扫描工具，并非对本发明的限制。
• ALBUMIN-BINDING CONJUGATES COMPRISING A FATTY ACID AND PEG
  申请人：UCB Biopharma SPRL

  公开号：EP1755684B1

  公开（公告）日：2016-08-31
• FATTY ACID MODIFIED POLYLYSINES AS ANTIMICROBIAL AGENTS
  申请人：Technion Research & Development Foundation Limited

  公开号：EP1793837A2

  公开（公告）日：2007-06-13
• HISTIDINE-CONTAINING DIASTEREOMERIC PEPTIDES AND USES THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO., LTD.

  公开号：EP1973556A2

  公开（公告）日：2008-10-01