Butyl 4-methyl-3-oxo-valerate | 51461-12-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: Butyl 4-methyl-3-oxo-valerate
• 英文别名: butyl 4-methyl-3-oxopentanoate
• CAS: 51461-12-2
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.25
• InChiKey: WIJMWXURIMFAHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  sodium hydroxide 、 Butyl 4-methyl-2-acetyl-3-oxo-valerate 、 、 盐酸 、 乙醚 在 Sodium sulfate-III 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 Butyl 4-methyl-3-oxo-valerate
  参考文献：
  名称：

  Catalyst component for olefin polymerization and catalyst comprising the same

  摘要：

  本发明提供了一种用于聚合烯烃CH2=CHR（其中R为氢或C1-C12烷基或芳基）的催化剂组分，包括镁、钛、卤素和电子给体化合物（a），所述电子给体化合物（a）至少选自公式（I）的二元酯化合物组中的一种，所述催化剂组分可选地进一步包括从脂肪族二羧酸酯和芳族二羧酸酯组成的电子给体化合物（b），和/或从公式（IV）的1,3-二醚化合物组中选择的电子给体化合物（c），其中R1、R'和A如描述中所定义，RI-RVIII如描述中所定义，以及包括所述催化剂组分的催化剂。

  公开号：

  US20060287446A1

文献信息

• Synthesis of epothilones, intermediates thereto, analogues and uses thereof
  申请人：Danishefsky J. Samuel

  公开号：US20080004450A1

  公开（公告）日：2008-01-03

  The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

  本发明提供了制备环毛蕊酮A和B，去氧环毛蕊酮A和B及其类似物的收敛工艺。还提供了与环毛蕊酮A和B相关的类似物和制备它们的中间体。本发明进一步提供了基于环毛蕊酮类似物的新型组合物，并提供了治疗癌症和多药耐药表型的癌症的方法。
• CATALYST COMPONENT FOR OLEFIN POLYMERIZATION REACTION AND CATALYST THEREOF
  申请人：China Petroleum & Chemical Corporation

  公开号：EP1746110A1

  公开（公告）日：2007-01-24

  The present invention provides a catalyst component for polymerization of olefin CH2=CHR, in which R is hydrogen or C1-C12 alkyl or aryl, comprising magnesium, titanium, a halogen and an electron donor compound (a) which is at least one selected from the group consisting of dibasic ester compounds of the formula (I), and said catalyst component optionally further comprising an electron donor compound (b) selected from the group consisting of aliphatic dicarboxylic esters and aromatic dicarboxylic esters, and/or an electron donor compound (c) selected from the group consisting of 1,3-diether compounds of formula (IV): wherein, R1, R' and A are as defined in the description, wherein RI-RVIII are as defined in the description, and a catalyst comprising the catalyst component.

  本发明提供了一种用于烯烃 CH2=CHR（其中 R 为氢或 C1-C12 烷基或芳基）聚合的催化剂组分，包括镁、钛、卤素和电子供体化合物 (a)，其中电子供体化合物 (a) 至少选自由式 (I) 的二盐基酯化合物组成的组、所述催化剂组分可选地进一步包括选自脂肪族二羧酸酯和芳香族二羧酸酯组成的组的电子供体化合物 (b)，和/或选自式 (IV) 的 1,3-二醚化合物组成的组的电子供体化合物 (c)： 其中，R1、R'和 A 如说明中所定义、 其中，RI-RVIII 如说明中所定义，以及由催化剂组分组成的催化剂。
• METHOD FOR FORMING MULTIPLE LAYERED COATING FILM AND COATED OBJECT
  申请人：Kansai Paint Co., Ltd

  公开号：EP2695680A1

  公开（公告）日：2014-02-12

  The invention provides a multilayer coating film-forming method that allows formation of a multilayer coating film with excellent smoothness, sharpness and water resistance, and which avoids or minimizes pinhole popping. The multilayer coating film-forming method of the invention has the following construction. A multilayer coating film-forming method comprising the following steps (1) to (4): step (1): coating an article to be coated with an aqueous first pigmented coating composition (X), step (2): coating the article to be coated, with an aqueous second pigmented coating composition (Y), step (3): coating the article to be coated, with a clear coating composition (Z), and step (4): heating an uncured first pigmented coating film, uncured second pigmented coating film and uncured clear coating film to cure them, wherein the aqueous first pigmented coating composition (X) contains a blocked polyisocyanate compound with a specific blocked isocyanate group.

  本发明提供了一种多层涂膜成膜方法，该方法可形成光滑度、锐利度和耐水性极佳的多层涂膜，并可避免或尽量减少针孔爆裂。本发明的多层涂膜成膜方法具有以下结构。一种多层涂膜成膜方法，包括以下步骤（1）至（4）： 步骤（1）：用水性第一颜料涂层组合物（X）涂覆待涂覆的物品； 步骤（2）：用水性第二颜料涂层组合物（Y）涂覆待涂覆的物品； 步骤（3）：用水性第二颜料涂层组合物（Y）涂覆待涂覆的物品：步骤 (4)：加热未固化的第一颜料涂膜、未固化的第二颜料涂膜和未固化的透明涂膜，使其固化，其中水性第一颜料涂膜组合物 (X) 包含具有特定封端异氰酸酯基团的封端多异氰酸酯化合物。
• BLOCKED POLYISOCYANATE COMPOUND
  申请人：Kansai Paint Co., Ltd

  公开号：EP2695902A1

  公开（公告）日：2014-02-12

  It is an object of the invention to provide a block polyisocyanate compound with excellent storage stability. The block polyisocyanate compound of the invention has the following construction. A block polyisocyanate compound having at least one block isocyanate group selected from the group consisting of a block isocyanate group represented by formula (I), block isocyanate group represented by formula (II) and block isocyanate group represented by formula (III), and a hydrophilic group.

  本发明的目的是提供一种具有优异储存稳定性的嵌段多异氰酸酯化合物。本发明的嵌段多异氰酸酯化合物具有如下结构。具有至少一个异氰酸酯嵌段基团的嵌段多异氰酸酯化合物，该异氰酸酯嵌段基团选 自由式（I）代表的异氰酸酯嵌段基团、由式（II）代表的异氰酸酯嵌段基团、由式 （III）代表的异氰酸酯嵌段基团和亲水基团组成的组。
• MULTILAYER FILM-FORMING METHOD AND COATED ARTICLE
  申请人：KANSAI PAINT CO., LTD.

  公开号：EP2818252A1

  公开（公告）日：2014-12-31

  An object of the present disclosure is to provide a method of forming a multilayer coating film that forms a multilayer coating film with excellent smoothness, distinctness of image, adhesion and water resistance when a plurality of uncured coating films are cured at once, and especially when they are cured at once at low temperature. The method of the present disclosure is as follows. A method of forming a multilayer coating film comprising the following steps 1-1 to 1-4: step 1-1: a step of coating an article to be coated with a primer coating composition (X) and forming an uncured primer coating film on the article to be coated, step 1-2: a step of coating the article to be coated having the uncured primer coating film with an aqueous colored coating composition (Y1) for a base coat, to form an uncured base coat coating film thereover, step 1-3: a step of coating the article to be coated having the uncured primer coating film and uncured base coat coating film, with a clear coating composition (Z), and forming an uncured clear coating film thereover, and step 1-4: a step of curing the uncured primer coating film, the uncured base coat coating film and the uncured clear coating film by heating them.

  本公开的一个目的是提供一种形成多层涂膜的方法，当多层未固化的涂膜一次固化时，尤其是在低温下一次固化时，该方法可形成平滑度、图像清晰度、附着力和耐水性极佳的多层涂膜。本公开的方法如下。 一种形成多层涂膜的方法，包括以下步骤 1-1 至 1-4： 步骤 1-1：用底涂涂料组合物（X）涂覆待涂覆物品并在待涂覆物品上形成未固化底涂涂膜的步骤， 步骤 1-2：用水性有色涂料组合物（Y1）涂覆具有未固化底涂涂膜的待涂覆物品，以作为底涂，在其上形成未固化底涂涂膜的步骤， 步骤 1-3：在具有未固化底漆涂膜和未固化基漆涂膜的待涂物品上涂覆透明涂料组合物 (Z)，并在其上形成未固化透明涂膜的步骤，以及步骤 1-4：通过加热固化未固化底漆涂膜、未固化基漆涂膜和未固化透明涂膜的步骤。