4-[2,3-bis(3-carboxypropanoyloxy)propoxy]-4-oxobutanoic acid | 10471-27-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[2,3-bis(3-carboxypropanoyloxy)propoxy]-4-oxobutanoic acid
• 英文别名: butanedioic acid, 1,1',1''-(1,2,3-propanetriyl) ester；glycerin trisuccinate；glycerol trisuccinate；glyceryl trisuccinate；succinic acid 1,2,3-propanetriyl ester；trisuccinylglycerol；UNII-80CAB03D7S；80CAB03D7S；TSG；SCHEMBL1405394；AGN-PC-0A97MT
• CAS: 10471-27-9
• 化学式: C₁₅H₂₀O₁₂
• 分子量: 392.317
• InChiKey: VZLNTRZYWUILOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  191
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 甘油 在 tin(ll) chloride 作用下， 生成 4-[2,3-bis(3-carboxypropanoyloxy)propoxy]-4-oxobutanoic acid
  参考文献：
  名称：

  Synthesis of a novel glycerol based B₃-type monomer and its application in hyperbranched polyester urethane–urea coatings

  摘要：

  用支化度几乎等于 66% 的超支化聚酯多元醇制备了具有高热稳定性（Tg - 124.9）的可再生基聚（尿烷-脲）涂料。

  DOI：

  10.1039/c5ra11712g

文献信息

• [EN] COMBINATION THERAPY<br/>[FR] TRAITEMENT COMBINÉ
  申请人：CARNOT LLC

  公开号：WO2017147220A1

  公开（公告）日：2017-08-31

  The present disclosure provides certain combination therapy technologies that are particularly useful for treating one or more diseases, disorders, or conditions that may be related to abnormal metabolism. In some embodiments, provided technologies provides combinations of TCA cycle acids and ketone bodies. In some embodiments, provided technologies provides combinations of TCA cycle acids and other carboxylic acids.

  本公开提供了一些特定的联合治疗技术，特别适用于治疗可能与异常代谢相关的一种或多种疾病、疾病或症状。在某些实施例中，提供的技术提供了TCA循环酸和酮体的组合。在某些实施例中，提供的技术提供了TCA循环酸和其他羧酸的组合。
• Combination therapy
  申请人：IMBRIA PHARMACEUTICALS, INC.

  公开号：US10786476B2

  公开（公告）日：2020-09-29

  The present disclosure provides certain combination therapy technologies that are particularly useful for treating one or more diseases, disorders, or conditions that may be related to abnormal metabolism. In some embodiments, provided technologies provides combinations of TCA cycle acids and ketone bodies. In some embodiments, provided technologies provides combinations of TCA cycle acids and other carboxylic acids.

  本公开提供了某些组合治疗技术，这些技术对于治疗可能与代谢异常有关的一种或多种疾病、失调或病症特别有用。在某些实施方案中，所提供的技术提供了 TCA 循环酸和酮体的组合。在某些实施方案中，所提供的技术提供了TCA循环酸和其他羧酸的组合。
• Anaplerotic agents for treatment of disorders of propionate and long chain fat metabolism
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US11083702B2

  公开（公告）日：2021-08-10

  Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG). Methods of restoring tricarboxylic acid (TCA) cycle function in a cell deficient for propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT) by contacting the cell with a succinate derivative or pro-drug, such as TSG, are also described.

  描述了治疗丙酸血症（PA）、甲基丙二酸血症（MMA）和脂肪酸氧化紊乱的方法。这些方法包括施用可直接进入三羧酸循环的无机物，如琥珀酸衍生物或原药，例如三琥珀酰甘油（TSG）。此外，还介绍了通过使细胞与琥珀酸衍生物或原药（如 TSG）接触来恢复缺乏丙酰-CoA 羧化酶（PCC）或甲基丙二酰-CoA 突变酶（MUT）的细胞的三羧酸（TCA）循环功能的方法。
• Dispenser bottle for at least two active fluids
  申请人：Muehlhausen Hans-Georg

  公开号：US20050139608A1

  公开（公告）日：2005-06-30

  A dispenser bottle having a first receiving container for a first active fluid and at least a second receiving container for a second active fluid, wherein the receiving containers each have a respective outlet for the active fluid and the outlets are arranged adjacently such that the two active fluids can be applied in a common application field of an application region, and wherein the outlets each comprise a respective discharge nozzle, which nozzles are spaced from one another such that the active fluids intermix only after departing the discharge nozzles.

  一种分配器瓶子，具有用于第一种活性流体的第一接收容器和用于第二种活性流体的至少第二接收容器，其中接收容器各自具有用于活性流体的出口，出口相邻排列，以便两种活性流体可以在应用区域的共同应用领域中应用，其中出口各自包括一个排放喷嘴，这些喷嘴彼此间隔，以便活性流体仅在离开排放喷嘴后才混合。
• POLYAMIDFORMMASSEN
  申请人：LANXESS Deutschland GmbH

  公开号：EP1966294A1

  公开（公告）日：2008-09-10