4-Cyano-2,3-dimethylpyrrol | 26187-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-Cyano-2,3-dimethylpyrrol
• 英文别名: 4,5-dimethyl-pyrrole-3-carbonitrile；4,5-dimethyl-1H-pyrrole-3-carbonitrile
• CAS: 26187-30-4
• 化学式: C₇H₈N₂
• mdl: MFCD19221220
• 分子量: 120.154
• InChiKey: BTYLHPMNFIDXMR-UHFFFAOYSA-N

物化性质

• 沸点：
  281.1±35.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  39.6
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] AMINOHETEROARYL KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES DE TYPE AMINOHÉTÉROARYLE
  申请人：ANRUI BIOMEDICAL TECH GUANGZHOU CO LTD

  公开号：WO2022111621A1

  公开（公告）日：2022-06-02

  Provided herein are novel compounds (e.g., Formula I or II), pharmaceutical compositions, and methods of using related to cyclin dependent kinases (CDKs). The compounds herein are typically CDK2 inhibitors, which can be used for treating a variety of diseases or disorders, such as cancer.

  本文提供了新型化合物（例如，公式I或II），制药组合物和使用方法，涉及到细胞周期蛋白依赖性激酶（CDKs）。这些化合物通常是CDK2抑制剂，可用于治疗各种疾病或障碍，例如癌症。
• PHOTOSTABLE CYANO-SUBSTITUTED BORON-DIPYRROMETHENE DYE AS GREEN EMITTER FOR DISPLAY AND ILLUMINATION APPLICATIONS
  申请人：BASF SE

  公开号：EP3810719A1

  公开（公告）日：2021-04-28
• [EN] PHOTOSTABLE CYANO-SUBSTITUTED BORON-DIPYRROMETHENE DYE AS GREEN EMITTER FOR DISPLAY AND ILLUMINATION APPLICATIONS<br/>[FR] COLORANT DE BORE-DIPYRROMÉTHÈNE PHOTOSTABLE SUBSTITUÉ PAR UN GROUPE CYANO COMME ÉMETTEUR VERT POUR LES APPLICATIONS D'AFFICHAGE ET D'ÉCLAIRAGE
  申请人：BASF SE

  公开号：WO2019243286A1

  公开（公告）日：2019-12-26

  The present invention relates to a color converter comprising a polymeric matrix mate- rial and at least one organic fluorescent colorant selected from a compound of formulae l.a, l.b, l.c or mixtures thereof R1, R2, R3, R5, R6, R7 are hydrogen, C1-C20-alkyl or C6-C14-aryl-C1-C10-alkylene, wherein the aryl moiety is unsubstituted or substituted by k substituents R9; R4a, R4b are fluorine, chlorine, cyano or OR10, R8a, R8b are C1-C20-alkyl; R8C is C1-C20-alkyl, C6-C10-aryl or C6-C10-aryl-C1-C10-alkylene, wherein the aryl moieties in two aforementioned radicals are unsubstituted or substituted by k substituents R9; k, R9 and R10 are as defined in the claims and in the description. The invention also describes the use of color converters; a backlight unit for liquid crystal displays; a liquid crystal display device and a self-emissive display device comprising this color converter and an ink formulation comprising a compound of formulae l.a, l.b or l.c and the use thereof.
• [EN] SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT<br/>[FR] DÉRIVÉ HÉTÉROARYLE SUBSTITUÉ, SON PROCÉDÉ DE PRODUCTION, ET COMPOSITION PHARMACEUTIQUE DESTINÉE À PRÉVENIR OU À TRAITER DES MALADIES LIÉES À LA PROTÉINE KINASE LE CONTENANT EN TANT QUE PRINCIPE ACTIF<br/>[KO] 치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
  申请人：DAEGU GYEONGBUK MEDICAL INNOVATION FOUND

  公开号：WO2020036437A1

  公开（公告）日：2020-02-20

  치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 치환된 헤테로아릴 유도체는 LRRK2를 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환의 치료 또는 예방에 유용하게 사용될 수 있다.