N-(2-Aminobutanoyl)-L-histidine | 91006-41-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Aminobutanoyl)-L-histidine
• 英文别名: (2S)-2-(2-aminobutanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
• CAS: 91006-41-6
• 化学式: C₁₀H₁₆N₄O₃
• mdl: MFCD13175138
• 分子量: 240.26
• InChiKey: SQCPKHUHTUECFZ-MQWKRIRWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• PROPHYLACTIC/THERAPEUTIC AGENT FOR STRESS-INDUCED BOWEL DISEASE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1864661A1

  公开（公告）日：2007-12-12

  Provided are a prophylactic/therapeutic agent for a stress-induced bowel disease, containing, as an active ingredient, at least one kind selected from the group consisting of histidine, a peptide comprising histidine, a precursor thereof and a pharmacologically acceptable salt thereof, a food/beverage having prophylactic/ameliorating action on the disease, a suppressant of the release of a chemical transmitter during stress induction, and a food/beverage having suppressive action on the release of the transmitter.

  本发明提供了一种应激诱导性肠病的预防/治疗剂，作为活性成分，至少含有一种选自组氨酸、由组氨酸组成的肽、其前体及其药理上可接受的盐、对该病具有预防/改善作用的食品/饮料、应激诱导期间化学递质释放抑制剂以及对递质释放具有抑制作用的食品/饮料组成的组。
• Biomarkers for cardiovascular diseases and methods using the same
  申请人：Metabolon, Inc.

  公开号：US10175233B2

  公开（公告）日：2019-01-08

  Biomarkers relating to cardiovascular disease, including atherosclerosis and cardiomyopathy, are provided, as well as methods for using such biomarkers as biomarkers for cardiovascular disease. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for cardiovascular disease, including atherosclerosis and cardiomyopathy.

  本研究提供了与心血管疾病（包括动脉粥样硬化和心肌病）有关的生物标志物，以及将此类生物标志物用作心血管疾病生物标志物的方法。此外，还提供了调节受试者相应疾病或状况的方法。还提供了作为心血管疾病（包括动脉粥样硬化和心肌病）生物标志物的成套小分子实体。
• Pharmaceutical, dietetic or veterinary compositions with eumetabolic activity
  申请人：SETRA S.r.l.

  公开号：EP0449787B1

  公开（公告）日：1995-09-27
• Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same
  申请人：Hu Yun Fu

  公开号：US20090155826A1

  公开（公告）日：2009-06-18

  Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
• Biomarkers for Prostate Cancer and Methods Using the Same
  申请人：Mitchell Matthew W.

  公开号：US20100292331A1

  公开（公告）日：2010-11-18

  Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.