2-Chlorobut-2-enedioyl dichloride | 17096-37-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 2-Chlorobut-2-enedioyl dichloride
• CAS: 17096-37-6
• 化学式: C₄HCl₃O₂
• 分子量: 187.4
• InChiKey: RFPNBTOAWCBYMT-UHFFFAOYSA-N

物化性质

• 沸点：
  268.17°C (rough estimate)
• 密度：
  1.5640

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Isoquinolines and preparation thereof
  申请人：Avera Pharmaceuticals, Inc.

  公开号：EP1380573A2

  公开（公告）日：2004-01-14

  A compound of Formula (III): wherein Y is selected from the group consisting of hydrogen or methoxy, W comprises a chiral center selected from the group consisting of a carbon atom having an R configuration and a carbon atom having an S configuration, n comprises 0 or 1, and A- comprises a pharmaceutically acceptable anion and process of preparation.

  式（III）化合物： 其中 Y 选自由氢或甲氧基组成的组，W 包括一个手性中心，该手性中心选自由具有 R 构型的碳原子和具有 S 构型的碳原子组成的组，n 包括 0 或 1，A- 包括一个药学上可接受的阴离子，以及制备方法。
• Substituted isoquinolines as ultra short acting neuromuscular blockers
  申请人：Avera Pharmaceuticals, Inc.

  公开号：EP1526130A1

  公开（公告）日：2005-04-27

  Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4; and X1 and X2 are independently halogen; ha and hb are independently from 0 to 2; Z1 and Z2 are independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl with the proviso that Z1 and Z are not both hydrogen; Y1, Y2, Y3 and Y4 are independently hydrogen, halogen or C1-C3 alkoxy; m and p are independently 1 to 6; n and r are independently 0 to 4; with the proviso that if ha and hb are both 0, then r is 0 and n is 0 to 2; R1 and R14 are independently hydrogen, halogen, C1-C3 alkoxy, or R2 and R3 together with the carbon atoms to which they are bonded, R5 and R6 together with the carbon atoms to which they are bonded, may independently form a methylenedioxy or ethylenedioxy moiety contained in a five- or six-membered ring; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.

  本发明公开了式（I）的超短效神经肌肉阻断剂，可在紧急插管过程、常规手术和术后环境中用作骨骼肌松弛剂、 其中 q 和 t 独立地为 0 至 4；X1 和 X2 独立地为卤素；ha 和 hb 独立地为 0 至 2；Z1 和 Z2 独立地为氢、C1-C6 烷基、C2-C6 烯基或 C2-C6 烷炔基，但 Z1 和 Z 不能都是氢；Y1、Y2、Y3 和 Y4 独立地为氢、卤素或 C1-C3 烷氧基；m 和 p 独立地为 1 至 6；n 和 r 独立地为 0 至 4；R1 和 R14 独立地为氢、卤素、C1-C3 烷氧基，或 R2 和 R3 与其键合的碳原子、R5 和 R6 与其键合的碳原子可独立地形成包含在五元或六元环中的亚甲二氧基或亚乙二氧基分子；W1 和 W2 为碳；以及 A 为药学上可接受的阴离子。
• SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP0971898A1

  公开（公告）日：2000-01-19
• SUBTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP0975599A1

  公开（公告）日：2000-02-02
• US3965148A
  申请人：——

  公开号：US3965148A

  公开（公告）日：1976-06-22