5-Methyl-L-histidine | 40519-43-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Methyl-L-histidine
• 英文别名: (2S)-2-amino-3-(5-methyl-1H-imidazol-4-yl)propanoic acid
• CAS: 40519-43-5
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.18
• InChiKey: UAFOEWLJICDDGE-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] POLYEHYLENE GLYCOL-PEPTIDE COPPER COMPLEXES AND COMPOSITIONS AND METHODS RELATED THERETO<br/>[FR] COMPLEXES DE POLYETHYLENE GLYCOL-PEPTIDE-CUIVRE ET COMPOSITIONS ET METHODES Y ETANT ASSOCIEES
  申请人：PROCYTE CORP

  公开号：WO2006023465A1

  公开（公告）日：2006-03-02

  This invention relates to compositions comprising polyethylene glycol molecules coupled to peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

  这项发明涉及包含聚乙二醇分子偶联到肽铜络合物的组合物，此外，还涉及配制用作药用和化妆品产品的这种组合物，以及包含这种组合物的医疗器械。
• Stimulation of hair growth by compositions containing peptide copper complexes and minoxidil
  申请人：ProCyte Corporation

  公开号：US20040142853A1

  公开（公告）日：2004-07-22

  Disclosed are compositions, useful for stimulating hair growth in warm-blooded animals in need thereof, that combine at least one peptide copper complex and Minoxidil. The disclosed compositions may be formulated so as to be suitable for topical application or for intradermal injection to areas of skin in need thereof. Also disclosed are methods for stimulating hair growth to thereby treat various hair growth afflictions, such as androgenetic alopecia, alopecia areata, or secondary alopecia. Generally, the disclosed methods comprise applying, topically or via intradermal injection, a stimulatory effective amount of a disclosed composition to an area of a patient's skin in need thereof. In one embodiment, the disclosed method employs such application in a continued and periodic fashion to arrest and/or reverse androgenetic alopecia.

  本发明公开了可用于刺激温血动物毛发生长的组合物，该组合物结合了至少一种肽铜复合物和米诺地尔。所公开的组合物可配制成适合局部应用或皮内注射到需要的皮肤区域。还公开了刺激毛发生长从而治疗各种毛发生长疾病的方法，如雄激素性脱发、斑秃或继发性脱发。一般来说，所公开的方法包括局部或通过皮内注射，将刺激有效量的所公开的组合物施用到患者需要的皮肤区域。在一个实施方案中，所公开的方法采用持续和定期施用的方式来阻止和/或逆转雄激素性脱发。
• Preserved and stable compositions containing peptide copper complexes and methods related thereto
  申请人：ProCyte Corporation

  公开号：US20040198639A1

  公开（公告）日：2004-10-07

  Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to microbial growth, when the preservative is selected to be a non-formaldehyde-donating preservative. In other embodiments, the present invention is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising a disclosed composition. In another aspect, the present invention is also directed to a method for imparting to a composition comprising at least one peptide copper complex, chemical stability as well as resistance and/or toxicity to microbial growth, where the method comprises incorporating a non-formaldehyde-donating preservative in the composition.

  包含至少一种肽铜复合物和至少一种防腐剂的组合物，当防腐剂被选择为非弃醛防腐剂时，肽铜复合物的化学稳定性以及对微生物生长的耐受性和/或毒性均有所表现。在其他实施方案中，本发明涉及配制成药品和化妆品的此类组合物，以及包含所公开组合物的医疗器械。在另一个方面，本发明还涉及一种方法，用于赋予包含至少一种肽铜络合物的组合物化学稳定性以及对微生物生长的抗性和/或毒性，其中该方法包括在组合物中加入一种非弃醛防腐剂。
• Compositions and methods for treatment of rosacea
  申请人：ProCyte Corporation

  公开号：US20040254097A1

  公开（公告）日：2004-12-16

  A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.

  一种治疗患者皮肤红斑痤疮的方法，是将一种包含至少一种肽铜复合物的组合物局部涂抹在受影响的皮肤上。在其他实施方案中，本发明针对的是这样一种方法，其中使用的组合物进一步包含某些已公开的活性剂，包括活性药物和活性化妆品物质。在一个相关方面，本发明的进一步实施方案涉及包含至少一种肽铜复合物和某些活性药物和活性化妆品物质的组合物，这些组合物使其在治疗酒渣鼻方面特别有效。
• Encapsulated peptide copper complexes and compositions and methods related thereto
  申请人：Patt M. Leonard

  公开号：US20050260275A1

  公开（公告）日：2005-11-24

  This invention relates to compositions comprising encapsulated peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

  本发明涉及包含封装肽铜复合物的组合物，此外，还涉及配制成药物和化妆品使用的此类组合物，以及包含此类组合物的医疗器械。