N-(4-(6-(4-chlorophenethoxy)pyridazin-3-yl)phenyl)-2-methylpropane-1-sulfonamide | 1252918-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(4-(6-(4-chlorophenethoxy)pyridazin-3-yl)phenyl)-2-methylpropane-1-sulfonamide
• 英文别名: N-[4-[6-[2-(4-chlorophenyl)ethoxy]pyridazin-3-yl]phenyl]-2-methylpropane-1-sulfonamide
• CAS: 1252918-07-2
• 化学式: C₂₂H₂₄ClN₃O₃S
• 分子量: 445.97
• InChiKey: UGCQLOJROGOYRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives
  申请人：de Hostos Eugenio L.

  公开号：US20110288093A1

  公开（公告）日：2011-11-24

  The present invention relates to methods for treating a disease in an animal, which disease is responsive to blocking of chloride channel by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof

  本发明涉及一种治疗动物疾病的方法，该疾病对通过给需要该药物的哺乳动物施用本文定义的化合物（包括表1-3中列出的化合物或公式I-III所包含的化合物）或其组合物阻断氯离子通道产生反应的有效量敏感。
• COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
  申请人：Penrose Stephen David

  公开号：US20120129858A1

  公开（公告）日：2012-05-24

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物疾病的组合物和方法，该疾病对通过给予需要的哺乳动物有效量的本文中定义的化合物（包括表1-3中列出的化合物或公式I-III所包含的化合物）或其组合物抑制功能性囊性纤维化跨膜传导调节因子（CFTR）多肽敏感，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。