2,4-Dithio-desoxythymidin | 28585-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2,4-Dithio-desoxythymidin
• 英文别名: 2,4-dithio-thymidine；2,4-Dithiothymidine；1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dithione
• CAS: 28585-52-6
• 化学式: C₁₀H₁₄N₂O₃S₂
• 分子量: 274.365
• InChiKey: YWVRYVKUVBITIN-XLPZGREQSA-N

物化性质

• 沸点：
  469.5±55.0 °C(Predicted)
• 密度：
  1.54±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Thiobase compounds for photodynamic therapy
  申请人：Case Western Reserve University

  公开号：US10413608B2

  公开（公告）日：2019-09-17

  A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.

  一种在光疗过程中使用化合物的方法包括：向需要治疗的受试者施用治疗有效量的硫代核苷酸、核苷、核苷酸和/或其类似物；并将所施用的化合物暴露于电磁辐射中。
• THIOBASE COMPOUNDS FOR PHOTODYNAMIC THERAPY
  申请人：Case Western Reserve University

  公开号：US20160206738A1

  公开（公告）日：2016-07-21

  A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.