Tricyclo-[3.2.2.02.4]-nonane-6,7-dicarboxylic acid anhydride | 54985-28-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tricyclo-[3.2.2.02.4]-nonane-6,7-dicarboxylic acid anhydride
• 英文别名: 4-oxatetracyclo[5.3.2.02,6.08,10]dodecane-3,5-dione
• CAS: 54985-28-3
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: NWWNOEMICJNZCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tricyclo-[3.2.2.02.4]-nonane-6,7-dicarboxylic acid anhydride 、 4-氨基丁基-1-(2-嘧啶)-哌嗪 在 吡啶 作用下， 生成 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]octahydro-4,6-ethanocycloprop[f]isoindole-1,3-(2H,3aH)-dione
  参考文献：
  名称：

  Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies

  摘要：

  A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests. Parameters measured included in vitro inhibition of D2 and 5-HT1A receptor binding, inhibition of apomorphine (APO) induced stereotyped and climbing behavior, and activity in blocking conditioned avoidance responding (CAR). Several compounds demonstrated moderate to high affinity for the 5-HT1A receptor binding site; compounds 27 and 36 containing the serotonin mimetic (o-methoxyphenyl)piperazinyl moiety and compounds 42 and 50 containing the 2-pyrimidinylpiperazinyl moiety displayed the highest affinity, being equal to that of the 5-HT1A agonist 8-OH-DPAT (Ki = 1-1.3 nM). In addition to affinity at 5-HT1A binding sites, many compounds were active in blocking CAR. Compound 34, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]hexahydro-4,7-etheno-1H- cyclobut[f]isoindole-1,3(2H)-dione, demonstrated 3 times the activity of buspirone, blocking CAR in rats with an AB50 of 13 mg/kg. It also displayed high affinity for the 5-HT1A receptor (Ki = 16 nM), which is at least 20 times higher than its affinity for D2 (Ki = 345 nM) and 5-HT2 (Ki = 458 nM) receptors. Compound 34 was selected for further preclinical and pharmacokinetic evaluations for possible development as an anxiolytic agent. Structure-activity relationships within this series are discussed.

  DOI：

  10.1021/jm00402a023

文献信息

• [EN] PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF<br/>[FR] DÉRIVÉS DE PYRIMIDINE ET DE PYRIDINE ET LEUR UTILISATION POUR TRAITER OU PRÉVENIR LA GRIPPE, OU POUR ATTÉNUER SES SYMPTÔMES
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2017133667A1

  公开（公告）日：2017-08-10

  Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.

  本文提供的是一种化合物，其化学式为（I），可以是药用盐、溶剂合物、多型体、前药、共药、共晶、互变异构体、消旋体、对映体或二对映体，或它们的混合物形式，该化合物在治疗、改善或预防流感方面具有用处。
• Insecticidal n-(substituted phenyl)-tricyclo [3,2,2,0.sup.2.4
  申请人：Ciba-Geigy Corporation

  公开号：US03993662A1

  公开（公告）日：1976-11-23

  New dicarboximides of the formula ##SPC1## Wherein R represents a phenyl mono- to trisubstituted, identically or differently, by fluorine, chlorine, bromine, iodine, trifluoromethyl, nitro, cyano, C.sub.1 --C.sub.4 -alkyl, methoxy or methylthio, or monosubstituted by a methylenedioxy group, and Z.sub.1 and Z.sub.2 each represent hydrogen, or together with the carbon atoms to which they are bound they represent a carbon-carbon bond And their use for controling insects are disclosed.

  公开了式子为##SPC1##的新二羧酸酰胺，其中R代表苯基单至三取代基，取代基可以相同或不同，包括氟、氯、溴、碘、三氟甲基、硝基、氰基、C.sub.1-C.sub.4烷基、甲氧基或甲硫基，或单取代为亚甲二氧基基团；Z.sub.1和Z.sub.2分别表示氢，或与它们结合的碳原子一起表示碳-碳键。这些化合物可用于控制昆虫。
• Compounds, Compositions and Methods for Treatment and Prevention of Orthopoxvirus Infections and Associated Diseases
  申请人：Jordan Robert

  公开号：US20100227892A1

  公开（公告）日：2010-09-09

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  使用二、三、四环腈肟衍生物及其类似物的方法，以及含有它们的制药组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
  申请人：Jordan Robert

  公开号：US20120020922A1

  公开（公告）日：2012-01-26

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  使用二、三、四环腈肟衍生物及类似物的方法，以及包含它们的制药组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• SILICON-CONTAINING RESIST UNDERLAYER FILM-FORMING COMPOSITION HAVING ORGANIC GROUP HAVING ALIPHATIC POLYCYCLIC STRUCTURE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170153549A1

  公开（公告）日：2017-06-01

  A resist underlayer film-forming composition for lithography having an aliphatic polycyclic structure including, as a silane, a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a combination thereof, in which the aliphatic polycyclic structure is a structure which a hydrolyzable silane of Formula (1): R 1 a R 2 b Si(R 3 ) 4−(a+b) Formula (1) (where R 1 is an organic group having an aliphatic polycyclic structure and bonded to a Si atom through a Si—C bond; R 3 is an ethoxy group; a is an integer of 1; b is an integer of 0 to 2; and a+b is an integer of 1 to 3) has, or a structure included in a compound added as an aliphatic polycyclic compound, an aliphatic polycyclic dicarboxylic acid, or an aliphatic polycyclic dicarboxylic acid anhydride, each optionally having a double bond, a hydroxy group, or an epoxy group.