4-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-oxobutanoic acid | 87458-26-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-oxobutanoic acid
• CAS: 87458-26-2
• 化学式: C₇H₁₁NO₅S
• 分子量: 221.23
• InChiKey: MXVUEJUCBIAFCN-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• USES OF AND METHODS OF TREATMENT WITH CYSTATHIONINE
  申请人：MCMASTEDR UNIVERSITY

  公开号：US20140163104A1

  公开（公告）日：2014-06-12

  The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. In one embodiment, a cystathionine synthesis inhibitor is administered to increase tumor cell apoptosis and/or increase the efficacy of chemo therapeutic treatment. More particularly, cystathionine can protect cells against toxin-induced cellular apoptosis and/or cystathionine synthesis inhibitors can increase neuroblastoma cell kill rates during chemotherapy.
• CYSTATHIONINE COMPOSITIONS AND METHODS OF TREATMENT FOR HEALTH CONDITIONS
  申请人：THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

  公开号：US20200352889A1

  公开（公告）日：2020-11-12

  The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. In one embodiment, a cystathionine synthesis inhibitor is administered to increase tumor cell apoptosis and/or increase the efficacy of chemotherapeutic treatment. More particularly, cystathionine can protect cells against toxin-induced cellular apoptosis and/or cystathionine synthesis inhibitors can increase neuroblastoma cell kill rates during chemotherapy.
• [EN] USES OF AND METHODS OF TREATMENT WITH CYSTATHIONINE<br/>[FR] UTILISATIONS DE LA CYSTATHIONINE ET MÉTHODES DE TRAITEMENT PAR LA CYSTATHIONINE
  申请人：UNIV COLORADO REGENTS

  公开号：WO2012167092A2

  公开（公告）日：2012-12-06

  The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. In one embodiment, a cystathionine synthesis inhibitor is administered to increase tumor cell apoptosis and/or increase the efficacy of chemo therapeutic treatment. More particularly, cystathionine can protect cells against toxin- induced cellular apoptosis and/or cystathionine synthesis inhibitors can increase neuroblastoma cell kill rates during chemotherapy.