2-Oxaspiro[3.4]octane-1,3-dione | 78503-61-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Oxaspiro[3.4]octane-1,3-dione
• CAS: 78503-61-4
• 化学式: C₇H₈O₃
• 分子量: 140.14
• InChiKey: LIBFVQBAZPYQCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS<br/>[FR] UTILISATIONS ET PROCÉDÉS COSMÉTIQUES POUR DES COMPOSITIONS D'INHIBITEUR D'INDOLINE GRANZYME B
  申请人：VIDA THERAPEUTICS INC

  公开号：WO2014153667A1

  公开（公告）日：2014-10-02

  Cosmetic uses and methods for indoline granzyme B inhibitor compounds in compositions with a cosmetically acceptable carrier. Uses and methods for treating, reducing or inhibiting the appearance of ageing in the skin are provided. Also provided are compositions and formulation for cosmetic uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subjecl. The uses and methods comprise applying/administering an indoline granzyme B inhibitor to a skin, or a portion of a skin of the subject.

  使用和方法用于在与化妆品可接受载体混合的化合物中使用吲哚啶颗粒酶B抑制剂。提供了用于治疗、减少或抑制皮肤衰老的用途和方法。还提供了用于化妆品用途的组合物和配方，以及保持年轻外观、减少衰老外观、抑制衰老外观、减少衰老外观速率、减少皮肤无弹性、减少增加皮肤无弹性速率、保持皮肤弹性和增加皮肤毛囊密度的方法。这些用途和方法包括将吲哚啶颗粒酶B抑制剂涂抹/施用于皮肤或受试者皮肤的部分。
• THERAPEUTIC AGENT FOR DIABETES
  申请人：Japan Tobacco Inc.

  公开号：EP0885869A1

  公开（公告）日：1998-12-23

  A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4 and R5 are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6 is a hydrogen atom or an amino-protecting group; R1 is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2 is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3 is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.

  用于治疗糖尿病的疗法剂，包括公式[I]的化合物 其中 X是公式的组 其中R4和R5相同或不同，每个都是氢原子，可选地取代的具有1至5个碳原子的烷基等等，R6是氢原子或氨基保护基团；R1是具有1至5个碳原子的可选取代烷基，具有2至6个碳原子的可选取代烯基等等，R2是氢原子，具有1至5个碳原子的可选取代烷基等等，R2'是氢原子，R3是具有1至5个碳原子的可选取代烷基等等，其前药，药用可接受盐，水合物和溶剂化物。 本发明的化合物在血糖升高状态下表现出优越的降血糖作用，但在正常范围或低血糖状态下不影响血糖，这意味着它没有低血糖等严重副作用。因此，本发明的化合物作为治疗糖尿病的药物很有用，也用作预防糖尿病慢性并发症。
• PROCESS FOR THE PREPARATION OF UNSATURATED CARBOXYLIC ACIDS BY CARBONYLATION OF ALLYL ALCOHOLS AND THEIR ACYLATION PRODUCTS
  申请人：BASF SE

  公开号：US20200055834A1

  公开（公告）日：2020-02-20

  The present invention relates to a process for carbonylating allyl alcohols at low temperature, low pressure and/or low catalyst loading. In an alternative embodiment, an acylation product of the allyl alcohol is used for the carbonylation. The present invention likewise relates to the preparation of conversion products of these carbonylation products and specifically of (−)-ambrox.

  本发明涉及一种在低温、低压和/或低催化剂负载下对烯丙醇进行羰基化的过程。在另一实施方式中，烯丙醇的酰化产物被用于羰基化。本发明还涉及制备这些羰基化产物的转化产物，特别是(−)-龙涎香。
• [EN] METHOD FOR THE ISOMERIZATION OF A 3-(Z)-UNSATURATED CARBOXYLIC ACID TO THE 3-(E)-ISOMER<br/>[FR] PROCÉDÉ D'ISOMÉRISATION D'UN ACIDE CARBOXYLIQUE 3-(Z)-INSATURÉ EN ISOMÈRE 3-(E)
  申请人：BASF SE

  公开号：WO2019158611A1

  公开（公告）日：2019-08-22

  The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula l-Z or a salt thereof, wherein R2 is C1-C24-alkyl, C2-C24-alkenylhaving 1, 2, 3 or more than 3 C-C double bonds, unsubstituted or substituted C5-C12-cycloalkyl, or unsubstituted or substituted aryl; R1 is hydrogen or has one of the definitions specified for R2; with the proviso that R2 has a higher priority than R1 in accordance with lUPAC; to give a 3-(E)-unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein the isomerization of the compound of the formula l-Z is effected in the presence of an anhydride of an organic acid and a base or in the presence of a ketene of formula CR11R12C(0), wherein R11 and R12 are as defined in the claims and in the specification and a base. In particular, the present invention relates to a method for preparing compositions with increased content of (3E, 7E)-homofarnesylic acid starting from compositions comprising (3Z,7E)- and (3E, 7E)-homofarnesylic acid.

  本发明涉及一种异构化3-(Z)-不饱和羧酸的方法，其化学式为l-Z或其盐，其中R2为C1-C24烷基，C2-C24烯基，具有1、2、3或多于3个C-C双键，未取代或取代的C5-C12环烷基或未取代或取代的芳基；R1为氢或具有R2指定的定义之一；在符合lUPAC的前提下，R2优先级高于R1，从而得到3-(E)-不饱和羧酸的化学式I-E或其盐。其中，在存在有机酸酐和碱或存在化学式为CR11R12C(0)的酮（其中R11和R12在权利要求和说明书中定义）和碱的情况下，对化合物l-Z进行异构化。特别地，本发明涉及一种制备含有增加的(3E,7E)-同型法尼酸的组合物的方法，其起始物为含有(3Z,7E)-和(3E,7E)-同型法尼酸的组合物。
• Coating varnish composition and antifouling coating composition
  申请人：HITACHI CHEMICAL CO., LTD.

  公开号：EP0608132A1

  公开（公告）日：1994-07-27

  The invention provides a coating varnish composition comprising (A) a polymer obtained by polymerizing (a) at least one unsaturated acid anhydride and (b) at least one other unsaturated monomer, and (B) at least one additive selected from triazole derivatives, benzothiazole derivatives, thiadiazole derivatives, polyethers and carboxylic acid anhydride derivatives and an antifouling coating composition comprising said coating varnish and an antifouling agent containing a coppercompound as major component. Using such compositions the risks of poisoning associated with organotin copolymers are avoided and there are obtained coatings of a coating consuming property and antifouling performance comparable with those of the organotin copolymers which do not gel even when mixed with a copper compound.

  本发明提供了一种涂料清漆组合物，该组合物包含(A)通过聚合(a)至少一种不饱和酸酐和(b)至少一种其他不饱和单体而得到的聚合物，和(B)至少一种选自三唑衍生物、苯并噻唑衍生物、噻二唑衍生物、聚醚和羧酸酐衍生物的添加剂，以及一种防污涂料组合物，该组合物包含上述涂料清漆和一种以铜化合物为主要成分的防污剂。使用这种组合物可以避免与有机锡共聚物有关的中毒风险，并获得涂层消耗特性和防污性能与有机锡共聚物相当的涂层，即使与铜化合物混合也不会凝胶。