Asp(Asp(OBzl)OBzl)-Asp(OBzl)OBzl | 1186099-21-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Asp(Asp(OBzl)OBzl)-Asp(OBzl)OBzl
• CAS: 1186099-21-7
• 化学式: C₄₀H₄₁N₃O₁₀
• 分子量: 723.78
• InChiKey: WOMMXMFBQFOFLS-AFEGWXKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  53.0
• 可旋转键数：
  19.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  189.42
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  Asp(Asp(OBzl)OBzl)-Asp(OBzl)OBzl 、 trindane-2,5,8-tricarboxylic acid 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs

  摘要：

  In this study, a series of aspartate based dendrimers with different cores were synthesized in a convergent approach and well characterized by NMR and MS techniques. The aqueous solubility of the model drugs (L-Histidine, Naproxen, Methotrexate) was measured in the presence of this kind of dendrimers at room temperature in PBS buffers at pH 6, 7 and 8. Results clearly confirmed that the solubility enhancement was due to presence of dendrimers at different pH compared to their corresponding aqueous solubility at different pH. The results indicated that the aspartate based dendrimers could be considered as an effective supplement of PAMAM dendrimers in solubility enhancement and drug delivery. The surface groups played an important role in dendrimer-mediated solubility enhancement.

  DOI：

  10.1016/j.ejmech.2010.01.069
• 作为产物：
  描述：

  Boc-Asp(Asp(OBzl)OBzl)-Asp(OBzl)OBzl 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 Asp(Asp(OBzl)OBzl)-Asp(OBzl)OBzl
  参考文献：
  名称：

  Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs

  摘要：

  In this study, a series of aspartate based dendrimers with different cores were synthesized in a convergent approach and well characterized by NMR and MS techniques. The aqueous solubility of the model drugs (L-Histidine, Naproxen, Methotrexate) was measured in the presence of this kind of dendrimers at room temperature in PBS buffers at pH 6, 7 and 8. Results clearly confirmed that the solubility enhancement was due to presence of dendrimers at different pH compared to their corresponding aqueous solubility at different pH. The results indicated that the aspartate based dendrimers could be considered as an effective supplement of PAMAM dendrimers in solubility enhancement and drug delivery. The surface groups played an important role in dendrimer-mediated solubility enhancement.

  DOI：

  10.1016/j.ejmech.2010.01.069

文献信息

• Designer peptide dendrimers using click reaction
  作者：V. Haridas、Yogesh K. Sharma、Srikanta Sahu、Ram P. Verma、Sandhya Sadanandan、Bharat G. Kacheshwar

  DOI：10.1016/j.tet.2011.01.023

  日期：2011.3

  We designed and synthesized various peptide dendrimers using a 1,3-dipolar cycloaddition (Click) reaction. The dendritic structures reported here include symmetrical, asymmetrical, and cationic dendrimers with triazole, cystine, aromatic, aliphatic, and Lys-Asp dipeptide cores. The high chemoselectivity of the click reaction allowed us to synthesize good yields of high-purity protected and unprotected dendritic structures. Triazole is an excellent peptide bond mimic, which remains hydrolytically stable. Dendrimer 15a and the core unit 21 gelate in a mixture of organic solvents. We also demonstrated the versatility of the design by synthesizing various carbohydrate-based dendrimers. (C) 2011 Elsevier Ltd. All rights reserved.