2,3-Dichloro-2-butenedioic acid | 43180-81-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-Dichloro-2-butenedioic acid
• 英文别名: 2,3-dichlorobut-2-enedioic acid
• CAS: 43180-81-0
• 化学式: C₄H₂Cl₂O₄
• 分子量: 184.96
• InChiKey: PNNFEYPWPCDLOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR PREPARING (4S, 6S)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO-[2,3-B]THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE AND ITS INTERMEDIATES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE (4S,6S)-4-(ÉTHYLAMINO)-5,6-DIHYDRO-6-MÉTHYL- 4H-THIÉNO-[2,3-B]THIOPYRAN-2-SULFAMIDE-7,7-DIOXYDE ET DE SES INTERMÉDIAIRES.
  申请人：MICRO LABS LTD

  公开号：WO2011101704A1

  公开（公告）日：2011-08-25

  Disclosed herein is an improved process for the preparation of (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7- dioxide (Dorzolamide) and its intermediates.

  本文披露了一种改进的制备过程，用于制备(4S,6S)-4-(乙基氨基)-5,6-二氢-6-甲基-4H-噻吩-[2,3-b]噻吩吡啶-2-磺酰胺-7,7-二氧化物（多索胺）及其中间体。
• Process for the preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0461401A1

  公开（公告）日：1991-12-18

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a source of ammonia and an appropriately substituted α,β-unsaturated aldehyde or ketone.

  提供了一种制备取代和未取代的2,3-吡啶二羧酸酯化合物的方法，通过将二烷基二氯马来酸酯与氨源和适当取代的α，β-不饱和醛或酮反应。
• Process for the preparation of dialkyl pyridine -2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0548559A1

  公开（公告）日：1993-06-30

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a dialkylamine to form an enamine intermediate and reacting said intermediate with an appropriately substituted α,β-unsaturated aldehyde or ketone and an ammonia source, as shown in Flow Diagam I:

  提供了一种制备取代和未取代的2,3-吡啶二甲酸酯化合物的方法，通过将二烷基二氯马来酸酯与二烷基胺反应形成恩酰亚胺中间体，并将该中间体与适当取代的α，β-不饱和醛或酮以及氨源反应，如流程图I所示。
• METHOD FOR PRODUCING 3,6-DICHLOROPYRIDAZINE-1-OXIDE
  申请人：Sankyo Agro Company, Limited

  公开号：EP1862461A1

  公开（公告）日：2007-12-05

  A process for preparing 3,6-dichloropyridazine-1-oxide which comprises reacting 3,6-dichloropyridazine with an acid anhydride and hydrogen peroxide of a concentration of 60% or less or a urea hydrogen peroxide addition compound.

  制备3,6-二氯吡嗪-1-氧化物的方法包括将3,6-二氯吡嗪与酸酐和浓度为60％或以下的过氧化氢或尿素过氧化氢加成物反应。
• [EN] NOVEL CHOLECYSTOKININ RECEPTOR LIGANDS<br/>[FR] NOUVEAUX LIGANDS D'UN RÉCEPTEUR DE LA CHOLÉCYSTOKININE
  申请人：PNB VESPER LIFE SCIENCE PVT LTD

  公开号：WO2014006629A1

  公开（公告）日：2014-01-09

  The present invention relates to novel compounds of formula (I): wherein X is selected from hydrogen, a halogen, or a substituent and R is selected from hydrogen, a halogen, phenyl, aryl as specified and Y is selected from H, hydroxy, as specified and R1 is selected from H, methyl, alkyl, C1-18 straight, branched or cyclic, saturated, unsaturated and aromatic hydrocarbyl groups, which aromatic groups may be heterocyclic, cyclic or acyclic and which may optionally be substituted by alkyl, alkynyloxycarbonyl, aryl, benzyl, arlyoxy, arylcarbonyl, aryloxycarbonyl, sulphur equivalents of said oxy, carbonyl and oxycarbonyl moieties, and oxo as specified. The invention also relates to their uses as CCK receptor ligands and CCK antagonists and their medicinal applications.

  本发明涉及式(I)的新化合物：其中X选自氢、卤素或取代基，R选自氢、卤素、苯基、指定的芳基，Y选自H、羟基、指定的基团，R1选自H、甲基、烷基、C1-18直链、支链或环状、饱和、不饱和和芳香族碳氢基团，其中芳香族基团可以是杂环、环状或非环状的，可以选择性地被烷基、炔氧羰基、芳基、苄基、芳氧基、芳基羰基、芳氧羰基、所述氧、羰基和氧羰基基团的硫等效物取代。本发明还涉及它们作为CCK受体配体和CCK拮抗剂的用途以及它们的医药应用。